[The peculiarities of chronic inflammation in elderly patients with gout and metabolic syndrome].

The patients with gout and metabolic syndrome have the chronic inflammation and the syndrome of endogenous intoxication. Characteristic of the latter is the prevalence of H-propanol, ethyl alcohol, methanol and uric acid in blood serum of the elderly patients.

[Endogenous toxemia in pancreatic necrosis of alcoholic etiology]. / Endointoksikatsiia pri pankreonekrozakh alkogol'noi etiologii.

Operation for pancreonecrosis was carried out in 197 patients, in 52 (26.4%) of them the disease was of alcoholic etiology. The disease was marked by severe clinical manifestations with the development of respiratory, hemodynamic, and peritoneal syndromes and their complications, and by psychic disorders. The endo-intoxication structure was studied in 13 patients by mass-spectrometry proceeding from alcohol metabolism in the organism. Eleven intermediate products were identified: ethanol, acetaldehyde, normal butyraldehyde and isovaleric aldehyde, diethylamine, acetone, isopropanol, methyl isocyanide, trimethylamine, ethannitrile. It was noted that the clinical manifestations of alcoholic pancreonecrosis are included in the spectrum of ethanol pharmacological action; the content of ethanol in the blood was tenfold of the normal, that of the product of its metabolism acetaldehyde was 1.6 times the normal level. Inclusion of exogenic ethanol in metabolism leads to its distortion and accumulation of substances of different origin in the organism, among which an important role is played by acetaldehyde, normal butyraldehyde, and isovaleric aldehyde. The results of the study create proconditions for the search for a rational means for their desactivation.

[Blood plasma kinin system status in mechanical jaundice and means for its correction]. / Sostoianie kininovoi sistemy plazmy krovi pri mekhanicheskoi zheltukhe i puti ee korrektsii.

The state of the kinin system in mechanical jaundice and possible ways for its normalization were analysed on the basis of clinico-experimental observations. In 32 patients with postoperative hepatic insufficiency developed against the background of mechanical jaundice a considerable activation of the kinin system was detected which was found to have a direct correlation with the severity of the disease. In experiments on 185 albino rats with model of mechanical jaundice during 40 days a comparative analysis of the state of the kinin system in the initial state, under conditions of hyperbaric oxygenation (HBO) and when using kontrikal and sodium salicylate against the background of HBO was made. The phasic activation of the kinin system was established. The use of HBO was found to maintain the antikinin activity during 30 days of jaundice. The effect of normalization was increased by the simultaneous use of sodium salicylate.

[Blood plasma kallikrein-kinin system in acute intestinal obstruction with the experimental use of hyperbaric oxygenation]. / Kallikrein-kininovaia sistema plazmy krovi pri ostroi kishechnoi neprokhodimosti v usloviiakh primeneniia giperbaricheskoi oksigenatsii v éksperimente.

The model of acute mechanical ileus was created in 130 albino rats. Components of the blood kinin system were investigated. During the second day the kinin system of blood was activated, during the third day it was depleted. The use of one performance of HBO on the 2nd and 3d day of ileus decreased the level of kinin-forming factors. The investigations performed create prerequisites for using HBO and antikinin drugs in the postoperative period of acute ileus, control of the kinin system parameters being strictly observed.