1.
Org Lett
; 13(5): 988-91, 2011 Mar 04.
Artigo
em Inglês
| MEDLINE
| ID: mdl-21265560
RESUMO
An efficient route toward the central ABC system of jiadifenin has been developed using two key Pd-catalyzed cyclizations. A protic solvent-activated Mizoroki-Heck reaction was used to construct the C(9) quaternary carbon and the A ring. A cascading Tsuji-Trost cyclization/lactonization sequence was employed to establish the BC ring system and the C(5,6) stereochemistry.