[Relation between the clinical course of acute myocardial infarction and specific sensitization of lymphocytes and lymphotoxin production]. / Klinicheskoe techenie ostrogo infarkta miokarda v zavisimosti ot spetsificheskoi sensibilizatsii limfotsitov i produktsii limfotoksina.

Seventy-eight patients with acute myocardial infarction (MI) were examined in order to assess the place of immune response caused by myocardial necrosis in the clinical pattern of the disease. The extent of autosensitization was estimated on the basis of E-RFC inhibition and lymphotoxin production in lymphocyte cultures in the presence of myocardial antigen. Sensitized lymphocytes emerge in the blood during the second week in primary acute MI, and during the first day in repeated acute MI. Patients with marked autosensitization more frequently developed recurrent anginal attacks and cardiovascular insufficiency; they were the only ones to show Dressler's syndrome and fatal outcomes. A positive correlation between cell sensitization and elevated IgG was seen during the third week of the disease. Lymphotoxin production tended to be increased in patients with repeated acute MI and Dressler's syndrome.

[Effect of nifedipine in chronic left ventricular insufficiency in patients with post-infarction heart aneurysm]. / Vliianie nifedipina pri khronicheskoi levozheludochkovoi nedostatochnosti u bol'nykh s postinfarktnoi anevrizmoi serdtsa.

A study was made of a vasodilating effect of nifedipine on the hemodynamics of 30 patients with chronic postinfarction left ventricular aneurysm, with chronic cardiovascular insufficiency of the II-III degree according to NYHA. A mean value of the acontractile segment on ventriculograms was 32.5 +/- 1.7%. The main parameters of systemic hemodynamics were studied by a method of integral body rheography 1 hour before and after sublingual intake of 20 mg of nifedipine (Corinfar, GDR) at rest, after exercise and during rehabilitation. An increase in the stroke and cardiac indices at rest by an average of 16% was revealed including a noticeable nifedipine effect in patients with elevated final diastolic pressure or arterial tension. During physical exercise a tendency toward an increase in the cardiac output was observed, mainly at the expense of a rise of the stroke volume after drug intake.