RESUMO
The processes of free-radical oxidation of proteins and lipids and superoxide dismutase activity were studied in neurons and neuroglia of the cerebral cortex in rats during ontogenesis and after prenatal stress. Regardless of age, normal animals were found to have higher levels of free-radical lipid and protein oxidation in neurons than in glia. This same pattern was also observed in relation to superoxide dismutase. After prenatal stress, the level of free-radical lipid oxidation decreased in 20-day-old rats in both neurons and neuroglia. Conversely, the level of free-radical protein oxidation products increased only in neurons, by an average factor of four. Superoxide dismutase activity in animals subjected to prenatal stress decreased significantly in neurons but did not change in neuroglia.
Assuntos
Córtex Cerebral/metabolismo , Radicais Livres/metabolismo , Imobilização/efeitos adversos , Proteínas do Tecido Nervoso/metabolismo , Neuroglia/metabolismo , Neurônios/metabolismo , Animais , Animais Recém-Nascidos , Córtex Cerebral/patologia , Feminino , Metabolismo dos Lipídeos , Masculino , Neuroglia/patologia , Neurônios/patologia , Oxirredução , Gravidez , Ratos , Ratos Wistar , Estresse Fisiológico , Superóxido Dismutase/metabolismoRESUMO
We studied the effect of prenatal stress on protein peroxidation in the plasma of rats during postnatal ontogeny. Oxidative destruction of proteins in prenatally stressed rats differed from that in control animals. These differences were most pronounced in postnatal ontogeny, i.e. during the development and maturation of CNS.
Assuntos
Proteínas Sanguíneas/metabolismo , Efeitos Tardios da Exposição Pré-Natal , Estresse Psicológico/metabolismo , Animais , Feminino , Crescimento , Oxirredução , Gravidez , Ratos , Ratos WistarRESUMO
We studied whether intranasal treatment with HSP70 can be used for the correction of maladaptive behavior in rats after unavoidable stress. After 3 intranasal injection of HSP70 in a dose of 3.25 microg we observed normalization of adaptive behavior after unavoidable stress and improvement of physiological reserves of the organism.
Assuntos
Proteínas de Choque Térmico HSP70/farmacologia , Estresse Psicológico/tratamento farmacológico , Administração Intranasal , Animais , Comportamento Animal/fisiologia , Estimulação Elétrica , Proteínas de Choque Térmico HSP70/administração & dosagem , Proteínas de Choque Térmico HSP70/metabolismo , Desamparo Aprendido , Masculino , Ratos , Ratos WistarRESUMO
Serum protein peroxidation was studied in rats with different strategy of adaptive behavior at rest and during short-term immobilization stress. Oxidative destruction of serum proteins was less intensive in KLA rats compared to that in KHA rats. Stress stimulated peroxidation of serum proteins in KHA rats.
Assuntos
Aprendizagem da Esquiva , Proteínas Sanguíneas/metabolismo , Peroxidação de Lipídeos , Estresse Fisiológico/fisiopatologia , Animais , Masculino , Ratos , Estresse Fisiológico/sangueRESUMO
Differences in the intensity of serum protein peroxidation were detected in pregnant rats with high and low peripheral nervous system excitability threshold in stress. Stress induced shifts in serum protein peroxidation, but these changes were opposite in rats of the two studied strains.
