Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 11 de 11
Filtrar
1.
bioRxiv ; 2024 Jun 14.
Artigo em Inglês | MEDLINE | ID: mdl-38915506

RESUMO

Accurate and timely diagnosis of oral squamous cell carcinoma (OSCC) is crucial in preventing its progression to advanced stages with a poor prognosis. As such, the construction of sensors capable of detecting previously established disease biomarkers for the early and non-invasive diagnosis of this and many other conditions has enormous therapeutic potential. In this work, we apply synthetic biology techniques for the development of a whole-cell biosensor (WCB) that leverages the physiology of engineered bacteria in vivo to promote the expression of an observable effector upon detection of a soluble molecule. To this end, we have constructed a bacterial strain expressing a novel chimeric transcription factor (Sphnx) for the detection of N-acetylneuraminic acid (Neu5Ac), a salivary biomolecule correlated with the onset of OSCC. This WCB serves as the proof-of-concept of a platform that can eventually be applied to clinical screening panels for a multitude of oral and systemic medical conditions whose biomarkers are present in saliva.

2.
bioRxiv ; 2024 Mar 27.
Artigo em Inglês | MEDLINE | ID: mdl-38586052

RESUMO

Aggregates of misfolded α-synuclein proteins (asyn) are key markers of Parkinson's disease. Asyn proteins have three domains: an N-terminal domain, a hydrophobic NAC core implicated in aggregation, and a proline-rich C-terminal domain. Proteins with truncated C-terminal domains are known to be prone to aggregation and suggest that studying domain-domain interactions in asyn monomers could help elucidate the role of the flanking domains in modulating protein structure. To this end, we used Gaussian accelerated molecular dynamics (GAMD) to simulate wild-type (WT), N-terminal truncated (DN), C-terminal truncated (ΔC), and isolated NAC domain variants (isoNAC). Using clustering and contact analysis, we found that N- and C-terminal domains interact via electrostatic interactions, while the NAC and N-terminal domains interact through hydrophobic contacts. Our work also suggests that the C-terminal domain does not interact directly with the NAC domain but instead interacts with the N-terminal domain. Removal of the N-terminal domain led to increased contacts between NAC and C-terminal domains and the formation of interdomain ß-sheets. Removal of either flanking domain also resulted in increased compactness of every domain. We also found that the contacts between flanking domains results in an electrostatic potential (ESP) that could possibly lead to favorable interactions with anionic lipid membranes. Removal of the C-terminal domain disrupts the ESP in a way that is likely to over-stabilize protein-membrane interactions. All of this suggests that one of the roles of the flanking domains may be to modulate the protein structure in a way that helps maintain elongation, hide hydrophobic residue from the solvent, and maintain an ESP that aids favorable interactions with the membrane.

3.
Global Spine J ; : 21925682241226659, 2024 Jan 10.
Artigo em Inglês | MEDLINE | ID: mdl-38197369

RESUMO

STUDY DESIGN: Retrospective chart review. OBJECTIVES: Lumbar interbody fusion (LIF) can be achieved with various techniques. Evidence supporting the long-term clinical advantages of one technique over another are inconclusive. The purpose of this study was to (1) determine the changes in sagittal parameters in the preoperative, intraoperative, and post-operative phase, (2) evaluate the radiographic maintenance of these parameters over time, and (3) compare the demographics and patient reported outcomes of patients undergoing various LIF techniques. METHODS: We performed a retrospective chart review of patients with degenerative spine disease undergoing single level anterior (ALIF), lateral (LLIF), posterior (PLIF), or transforaminal (TLIF) lumbar interbody fusion. Data collected included patient demographics and diagnosis at time of surgery. Upright lumbar radiographs taken pre-operatively, intra-operatively, and post-operatively were measured for lumbar lordosis (LL), segmental lordosis (SL), posterior disc height (PDH), and foraminal height (FH). RESULTS: 194 patients in a single center were included. PDH and FH increased intra-operatively following ALIF (P < .0001), PLIF (P < .0001), LLIF (P < .0001), and TLIF (P < .0001). SL also increased intra-operatively for ALIF (P = .002) and LLIF (P = .0007). Compared to intra-operative radiographs, PDH and FH decreased at latest post-operative phase for ALIF (P < .03), LLIF (P < .003), TLIF (P < .001), and PLIF (P < .005). SL decreased for ALIF (P = .0008), and TLIF (P = .02). LL did not change postoperatively across techniques. Patient reported outcomes improved post-surgically and disability index decreased, but neither differed between techniques. CONCLUSION: LIF, regardless of technique, was shown to provide significant radiographic changes in PDH and FH. Techniques utilizing larger intervertebral cage sizes (ALIF/LLIF) improved SL. Single level LIF did not affect overall LL. No single technique displayed superior radiographic robustness over time.

4.
Arch. méd. Camaguey ; 26: e8755, 2022.
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1403296

RESUMO

RESUMEN Introducción: La apendicitis aguda es una de las causas más frecuentes de abdomen agudo. Objetivo: Describir las tendencias actuales en el tratamiento de la apendicitis aguda en adultos. Métodos: Se realizó una revisión no sistemática de la literatura en las bases de datos: Biblioteca Virtual de Salud, PubMed, SciELO y Google académico. Se incluyeron metanálisis y trabajos originales disponibles a texto completo publicados desde 2016 hasta marzo de 2021, en idiomas inglés y español. Resultados: El más aceptado tratamiento a nivel mundial es la apendicectomía laparoscópica para el tratamiento de las formas complicadas y no complicadas de apendicitis aguda siempre y cuando existan las condiciones materiales y humanas para su realización, es preferible la ligadura simple del muñón apendicular a la invaginación. El uso sistemático de drenajes abdominales no es beneficioso. Los protectores de los bordes de la incisión son útiles en la prevención de la infección del sitio quirúrgico. El cierre primario de la piel mediante una sutura intradérmica tiene mejores resultados. Es necesario clasificar de manera uniforme la enfermedad para un mejor manejo. Los antimicrobianos profilácticos son suficientes en las formas no complicadas, en complicados, un curso corto de antibióticos es efectivo. El tratamiento conservador puede ser considerado seguro y efectivo en pacientes seleccionados con apendicitis aguda no complicada. Conclusiones: La apendicectomía laparoscópica es el abordaje más aceptado, con tendencia al uso de protocolos de tratamiento ambulatorio y menor duración de los antimicrobianos.


ABSTRACT Introduction: Acute appendicitis is one of the most common causes of acute abdominal pain. Objective: To describe currents trends in treatment of acute appendicitis in adults. Methods: A non-systematic review of the literature was made using Virtual Health Library, PubMed, SciELO and Scholar Google databases. Meta-analysis and original articles, in Spanish and English, published from 2016 to March 2021, were included. Results: Laparoscopic appendectomy is the most accepted treatment for complicated and uncomplicated forms of acute appendicitis, were human and materials resources exists. Simple ligation is preferable to stump invagination. The systematic use of abdominal drainage is not recommended. Wounds edge protectors are useful in prevention of surgical site infection. Primary skin closure with an intradermal suture, has better results. To achieve a unique disease classification system is necessary, in order to improve results. Prophylactic antibiotics are sufficient in uncomplicated appendicitis; complicated acute appendicitis require a short course of antibiotics. Non-surgical treatment can be considered in selected patients with uncomplicated acute appendicitis. Conclusions: Currently, laparoscopic appendectomy is preferred, there is a tendency to use ambulatory protocols and shortened antibiotics prescriptions.

5.
Arch. méd. Camaguey ; 26: e8907, 2022. graf
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1403307

RESUMO

RESUMEN Introducción: Los tumores pancreáticos en el embarazo son muy raros, el diagnóstico y tratamiento en este grupo de pacientes es complejo. Objetivo: Presentar el primer caso de un leiomioma primario del páncreas en una gestante. Caso clínico: Embarazada de 26 años de edad, sin antecedentes relevantes. Primigesta, que se encontraba cursando la semana 13 de gestación. Durante una evaluación ecográfica de rutina, se le detecta una tumoración en la glándula pancreática. Se remitió a la consulta multidisciplinaria de atención a la materna y en conjunto deciden realizar la interrupción voluntaria del embarazo. Luego la paciente fue remitida a la consulta de la especialidadde Cirugía General. Al recibir a la misma, se quejaba de dolor en epigastrio e hipocondrio izquierdo, además de hipo ocasional. Al examen físico se encontró una tumoración palpable en epigastrio. Se realizaron exámenes analíticos básicos sin encontrarse alteraciones, en los estudios de imagen realizados, ecografía abdominal y tomografía contrastada de abdomen se demostró una tumoración en el cuerpo y cola del páncreas. Se planificó tratamiento quirúrgico electivo, se realizó pancreatectomía distal con esplenectomía, por invasión del estómago, se complementó con gastrectomía subtotal. La paciente evoluciona sin complicaciones. La biopsia informó un tumor mesenquimal benigno primario de páncreas, tipo leiomioma, bien encapsulado. Conclusiones: Se presenta el primer caso de un leiomioma primario del páncreas en una gestante. Los tumores pancreáticos en embarazadas son enfemedades raras, el manejo por un equipo multidisciplinario es la mejor forma de obtener resultados satisfactorios para la paciente.


ABSTRACT Introduction: Pancreatic tumors during pregnancy are very rare, diagnosis and treatment are always difficult. Objective: To present the first case of a primary pancreatic leiomyoma in a pregnant woman. Case report: A 26 years old primiparous pregnant is reported, with no relevant backgrounds. She was in her first trimesters of pregnancy. Diagnosed with a pancreatic tumor during a routine evaluation. She was referred to a multidisciplinary consult, deciding the voluntary interruption of pregnancy, then she is evaluated by the General Surgery specialty clinic for complaining of epigastric pain and hiccup. On physical examination an epigastric tumor was found. Auxiliary exams were normal. Imagenologic studies confirm a tumor in the pancreatic body and tail. Surgical treatment was scheduled, distal pancreatectomy with splenectomy, due to invasion of gastric wall subtotal distal gastrectomy was performed. Patient evolution without complications. Biopsy reported a well capsulated, leiomyoma type, primary mesenchymal pancreatic tumor. Conclusions: The first case of a primary pancreatic leiomyoma in a pregnant woman is presented. Pancreatic tumors during pregnancy are rare. Multidisciplinary approach is the best way to improve results.

6.
Arch. méd. Camaguey ; 25(6): e8505, 2021. tab, graf
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1355657

RESUMO

RESUMEN Fundamento: la apendicitis aguda es uno de los diagnósticos más comunes en pacientes con abdomen agudo. Su diagnóstico puede ser mejorado con el uso de sistemas de puntaje clínicos. Objetivo: describir los resultados obtenidos con el uso de la escala de Alvarado para el diagnóstico de apendicitis aguda en un hospital municipal. Métodos: se realizó un estudio observacional, descriptivo, transversal en pacientes atendidos en el Hospital Manuel Piti Fajardo, del municipio Florida, provincia Camagüey desde enero a diciembre de 2020. El universo lo conformaron los pacientes operados con diagnóstico de apendicitis aguda, se excluyeron aquellos con diagnóstico transoperatorio diferente y con plastrón apendicular. Se utilizaron como variables independientes: sexo, edad, tiempo de evolución de la enfermedad, datos clínicos al ingreso, estudios diagnósticos realizados y sus resultados. La puntuación en la escala de Alvarado fue la variable dependiente. Se tomaron los datos de las historias clínicas y se registró en un formulario creado al efecto. Resultados: se trataron 43 pacientes, el grupo de edad más afectado fue de 20 a 40 años, predominó el sexo masculino. La mayoría de los pacientes acudieron con menos de 24 horas de evolución. El dolor a la palpación en el cuadrante inferior derecho y el dolor de rebote fueron los principales datos clínicos. El leucograma con diferencial fue el estudio auxiliar más realizado. La mayoría de los pacientes tuvieron una puntuación de alto riesgo en la escala de Alvarado. Conclusiones: la escala de Alvarado es una herramienta útil para el diagnóstico de apendicitis aguda en los servicios de urgencias.


ABSTRACT Background: acute appendicitis is one of the most common diagnoses among patients with acute abdomen. Diagnosis can be improved by using clinical scoring systems. Objective: to describe the results obtained with the Alvarado score for the diagnosis of acute appendicitis in a municipal hospital. Methods: a descriptive, cross-sectional and retrospective study was carried out at the Manuel Piti Fajardo Hospital in Florida municipality, Camagüey province, from January to December 2020. The universe consisted of all patients operated on with acute appendicitis diagnosis, excluding those with different diagnosis and appendiceal mass. Independent variables were sex, age, time of evolution of the disease, clinical data at admission, auxiliary studies and their results. Alvarado score was the dependent variable. The medical records and a prepared spread sheet were used as a source to empty the data. Results: 43 patients were treated whit acute appendicitis; the age group more affected was that of 20 to 40 years old, male sex was predominant. Mostly the patients had less than 24 hours of the disease. Tenderness and rebound pain in the right lower quadrant were the mains clinical data. White blood cell count was the more frequent study. The majority of the patients had a high risk score in Alvarado scoring system. Conclusions: high risk score in Alvarado scoring system was predominant, age between 20 and 40 years old, male gender and positive results in auxiliary studies were related whit a higher score.

7.
Medisur ; 19(3): 524-529, 2021. graf
Artigo em Espanhol | LILACS | ID: biblio-1287334

RESUMO

RESUMEN: La ingestión intencional de cuerpos extraños es frecuente entre prisioneros. Es un fenómeno asociado a un aumento de la morbimortalidad y los costos. Generalmente no requiere de intervención específica, aunque pueden aparecer complicaciones severas, que requieren, en ocasiones, tratamiento quirúrgico urgente. Se presenta un paciente masculino, de 24 años de edad, sin antecedentes relevantes, recluido en la prisión de máxima seguridad de la provincia Camagüey. Se introdujo por la boca un alambre de 40 cm de longitud, con un gancho en su punta. Presentó sialorrea y molestias retroesternales. Al examen físico se encontró normalidad de sus parámetros vitales, sin alteraciones en el examen del tórax, con abdomen doloroso a la palpación profunda del cuadrante inferior derecho. Se realizaron radiografías simples de tórax posteroanterior, lateral, y de abdomen simple, se encontraron un cuerpo extraño desde la boca hasta el tercio inferior del esófago torácico y otro cuerpo extraño ubicado en la pelvis, que refirió haber ingerido intencionalmente hace un año. Se realizó laparotomía urgente y extracción de ambos cuerpos extraños. El paciente evolucionó satisfactoriamente sin desarrollar complicaciones. La ingestión intencional de cuerpos extraños en la población penal es un problema de salud complejo. La prevención es uno de los pilares fundamentales de su tratamiento. Es importante un alto índice de sospecha sobre la ingestión de múltiples objetos, en este grupo de pacientes la cirugía es frecuentemente requerida.


ABSTRACT The conscious ingestion of foreign bodies is frequent among prisoners. It is a phenomenon associated with an increase in morbidity - mortality and costs. Generally, it does not require specific intervention, although severe complications may appear, which sometimes require urgent surgical treatment.to present the case of a prisoner with recurrent intentional ingestion of multiple foreign bodies, one of them not previously diagnosed. Case presentation: A 24-years-old male patient, with no relevant history, held in the Camagüey province maximum security prison. The wire was introduced through the mouth 40 cm long, with a hook at its tip. Referring to hypersalivation and retrosternal discomfort. The physical examination found normality of his vital parameters, without alterations in the chest examination, with a painful abdomen on deep palpation of the right lower quadrant. A posteroanterior and lateral chest X-ray was performed, finding a foreign body from the mouth to the lower third of the thoracic esophagus, an abdominal X-ray where another foreign body was located in the pelvis, which he reported having intentionally ingested a year ago. An urgent laparotomy was performed and both foreign bodies were removed. The patient evolves satisfactorily without developing complications. The intentional ingestion of foreign bodies in the prison population is a complex health problem. Prevention is one of the fundamental pillars of its treatment. A high index of suspicion on the ingestion of multiple objects is important; in this group of patients surgery is frequently required.


Assuntos
Humanos , Masculino , Adulto , Prisioneiros/psicologia , Raios X , Custos e Análise de Custo , Corpos Estranhos/complicações , Exame Físico , Indicadores de Morbimortalidade , Corpos Estranhos/terapia
8.
Arch. méd. Camaguey ; 25(3): e7848, 2021. tab, graf
Artigo em Espanhol | LILACS-Express | LILACS | ID: biblio-1285172

RESUMO

RESUMEN Fundamento: la histerectomía es el procedimiento quirúrgico ginecológico más realizado a nivel mundial. En la actualidad no existe consenso sobre la vía de abordaje, donde es un problema a resolver. Objetivo: comparar los resultados de la aplicación de la histerectomía vaginal y la vaginal asistida por laparoscopia en pacientes con afecciones benignas del útero sin prolapso uterino. Métodos: se realizó un estudio descriptivo, transversal y retrospectivo en el Hospital Universitario Manuel Ascunce Domenech de la provincia Camagüey desde enero de 2017 a septiembre de 2019. El universo estuvo formado por todas las pacientes con enfermedades benignas del útero excluyendo el prolapso, operadas con las técnicas de histerectomía vaginal convencional y la asistida por laparoscopia en el período de estudio. Como fuente se utilizaron las historias clínicas y una planilla confeccionada para vaciar los datos. La variable dependiente fue: resultados que se clasificaron en satisfactorios o insatisfactorios. Las variables independientes fueron: edad, método quirúrgico, indicación quirúrgica, paridad, cirugías abdominales previas, tiempo quirúrgico, pérdidas sanguíneas transoperatorias, complicaciones y estadía hospitalaria. Resultados: predominó la histerectomía vaginal convencional a la asistida por laparoscopia. No existieron resultados insatisfactorios en ninguno de los dos grupos. El grupo de edad que prevaleció fue el de 40 a 49 años. La mayoría de las enfermas eran multíparas y sin antecedentes de cirugías previas. La histerectomía vaginal convencional mostró menor tiempo quirúrgico y las pérdidas sanguíneas fueron menores de 250 ml, con ambas técnicas. Las complicaciones de mayor frecuencia fueron las relacionadas con la cúpula vaginal, la estadía hospitalaria que predominó fue menor de 24 horas. Conclusiones: la histerectomía vaginal convencional, así como la asistida por la laparoscopia constituyen las técnicas quirúrgicas de elección ante las enfermedades benignas del útero que no sean el prolapso, en aquellas instituciones con personal entrenado y equipamiento necesario para su realización.


ABSTRACT Background: hysterectomy is the most widely performed gynecological surgical procedure worldwide. Currently, there is no consensus on when to use one or the other approach, which is a problem to solve. Objective: to compare the results of the application of laparoscopic-assisted vaginal and vaginal hysterectomy in patients with benign conditions of the uterus without uterine prolapse. Methods: a descriptive, cross-sectional and retrospective study was carried out at the Manuel Ascunce Domenech University Hospital in the period from January 2017 to September 2019. The universe consisted of all patients with benign diseases of the uterus excluding prolapse, who underwent surgery with conventional vaginal hysterectomy and laparoscopic assisted techniques in the study period. The medical records and a prepared spreadsheet were used as a source to empty the data. The dependent variable was the results; it was classified as satisfactory or unsatisfactory. Independents variables were: age, surgical method, surgical indication, parity, previous abdominal surgeries, surgical time, intraoperative blood loss, surgical complications, and hospital stay. Results: the conventional vaginal hysterectomy technique predominated over the one assisted by laparoscopy. There were not unsatisfactory results in no one of the two groups. The age group that prevailed in the patients was that of 40 to 49 years. Most of the patients were multiparous and had no history of previous abdominal surgeries. Conventional vaginal hysterectomy showed less surgical time and blood losses were less than 250 ml, with both techniques. The most frequent complications were related to vaginal cupules, as well as the prevailing hospital stay was less than 24 hours. Conclusions: conventional vaginal hysterectomy, as well as laparoscopic-assisted hysterectomy, are the surgical techniques of choice for patients with benign uterine diseases other than prolapse, in those institutions where there are trained personnel and the necessary equipment to carry them out.

9.
Neuroradiol J ; 27(6): 718-24, 2014 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-25489896

RESUMO

Endovascular therapy is a well-established approach to the treatment of cerebral arteriovenous malformations (AVMs). The objective of this study was to determine the predictive factors of neurological deficit following endovascular procedures. Seventy-one patients with cerebral AVMs who underwent 147 embolization sessions from 2006 to 2011 were followed up prospectively (average 31.1 ± 17.5 months). Functional neurological condition was documented by means of the modified Rankin scale. Factors found to be predictors of neurological deficit were the partial obstruction of drainage veins (OR = 197.6; IC = 2.76 -1416.0; P = 0.015), a positive result in the Propofol test (OR = 50.2; IC = 6.18 - 566.5; P = 0.000), AVM diameter under 3 cm (OR = 21.3; IC: 1.71 - 265.6; P = 0.018), the presence of intranidal aneurysms (OR = 11.2; IC = 1.09 - 114.2; P = 0.042), the absence of post-procedure hypotension (OR = 10.2; IC = 1.35 - 77.7; P = 0.003), deep venous drainage (OR = 7.14; IC = 1.15 - 44.4; P = 0.035), and devascularization in excess of 40% per session (OR = 3.3; IC = 1.11 - 16.8; P = 0.056). Fifty-six patients (78.9%) did not experience changes in their neurological condition after the treatment and 13 patients (18.3%) showed a new neurological deficit related to the treatment; 95.8 % of the patients did not show significant long-term incapacity. Partial obstruction of drainage veins, small AVMs, intranidal aneurysms, faulty hemodynamic control and extensive devascularization were found to be predictors of neurological deficit. A significant number of patients with neurological deficit improved in the long term.


Assuntos
Embolização Terapêutica/efeitos adversos , Procedimentos Endovasculares/efeitos adversos , Malformações Arteriovenosas Intracranianas/terapia , Doenças do Sistema Nervoso/etiologia , Feminino , Seguimentos , Humanos , Masculino , Estudos Prospectivos , Fatores de Risco , Resultado do Tratamento
10.
Interv Neuroradiol ; 20(1): 74-82, 2014.
Artigo em Inglês | MEDLINE | ID: mdl-24556303

RESUMO

Post-embolization hemorrhage is the most severe, dramatic and morbidity-mortality-related complication in the treatment of endovascular arteriovenous malformations (AVMs). The objective of this study was to determine predictive factors of post-embolization hemorrhage. This is a retrospective study in 71 patients with cerebral AVMs having undergone 147 embolization sessions with n-butyl cyanoacrylate (n-BCA), carried out between 2006 and 2011. Clinical-demographic, morphological and treatment data as well as results were recorded. The relationship of post-procedure hemorrhage with demographic and morphological factors, percentage devascularization per session, venous drainage and whether or not post-procedure hypotension had been induced was investigated. Six post-embolization hemorrhages occurred, all in sessions characterized by extensive devascularization without the induction of post-procedure hypotension; which disappeared after a limit to the extent of devascularization per session and post-procedure hypotension were introduced. In the multivariate analysis, hemorrhage predictors were: nidus diameter < 3 cm (OR= 45.02; CI=95%:1.17-203.79; P=0.005); devascularization > 40% (OR=32.4; CI=95%: 3.142- 518.6; P=0.009) per session; intranidal aneurysms (OR=7.5; CI=95%:1.19-341.3; P=0.041) and lack of post-procedure hypotension (OR=16.51; CI=95%:1.81-324.4; P=0.049) and the association of sessions with devascularization exceeding 40% with lack of post-procedure hypotension, showed an increase in the risk of hemorrhage (OR=36.4; CI=95%:3.67-362.4; P=0.002). Extensive devascularization and the absence of post-procedure hypotension increase the risk of hemorrhage. We suggest partial, 25-30%, devascularization per session and the induction of post-procedure hypotension, which produces a 20% decrease of the basal mean arterial pressure (MAP).


Assuntos
Fístula Arteriovenosa/epidemiologia , Fístula Arteriovenosa/terapia , Hemorragia Cerebral/epidemiologia , Embolização Terapêutica/estatística & dados numéricos , Embucrilato/uso terapêutico , Malformações Arteriovenosas Intracranianas/epidemiologia , Malformações Arteriovenosas Intracranianas/terapia , Adolescente , Adulto , Idoso , Causalidade , Hemorragia Cerebral/prevenção & controle , Criança , Comorbidade , Cuba/epidemiologia , Feminino , Hemostáticos/uso terapêutico , Humanos , Incidência , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Fatores de Risco , Resultado do Tratamento , Adulto Jovem
11.
Neuroradiol J ; 27(1): 108-14, 2014 Feb.
Artigo em Inglês | MEDLINE | ID: mdl-24571841

RESUMO

Endovascular therapy is a therapeutic option that can achieve total obliteration of cerebral arteriovenous malformations (AVMs). The objective of this study was to determine the predictive factors of total obliteration in the endovascular treatment of AVMs. A prospective study was carried out in 71 patients with cerebral AVMs having undergone 147 embolization sessions with n-BCA, performed between 2006 and 2011. A univariate analysis was carried out, followed by a logistic regression analysis to determine the predictive factors of total obliteration. Total obliteration was achieved in 18.3% of the patients and angiographic control after 12 months showed the permanency of total occlusion in 100% of the AVMs with initial total obliteration. Angiographic characteristics found favorable for total eradication were: AVM size under 3 cm and the presence of a single arterial pedicle. Predictive factors of total obliteration were an AVM diameter smaller than 3 cm (OR: 50.9; IC: 7.41 - 349, 0; P = 0.000), and opposing factors, a 3-6 cm diameter (OR: 11.7; IC: 2.49 - 55, 4; P = 0.002) and afferences of more than two vessels of the Willis polygon (OR: 7.0; IC: 1.12-43.9; P = 0.038). An AVM diameter smaller than 3 cm is a predictive factor of total obliteration. Total postembolization obliteration persisted in 100% of the cases after 12 months.


Assuntos
Procedimentos Endovasculares/métodos , Malformações Arteriovenosas Intracranianas/cirurgia , Adolescente , Adulto , Idoso , Angiografia Digital , Angiografia Cerebral , Revascularização Cerebral , Criança , Embolização Terapêutica , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Valor Preditivo dos Testes , Estudos Prospectivos , Resultado do Tratamento , Adulto Jovem
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...