RESUMO
OBJECTIVE: To assess effectiveness and safety of certolizumab PEGol (CZP) in rheumatoid arthritis (RA) patients after 12 months of treatment and to detect predictors of response. METHODS: Observational longitudinal prospective study of RA patients from 35 sites in Spain. Variables (baseline, 3- and 12-month assessment): sociodemographics, previous Disease Modifying Anti-Rheumatic Drug (DMARD) and previous Biological Therapies (BT) use; TJC, SJC, ESR, CRP, DAS28, SDAI. Response variables: TJC, SJC, CRP, ESR, and steroids dose reductions, EULAR Moderate/Good Response, SDAI response and remission, DAS28 remission. Safety variables: discontinuation due to side-effects. Descriptive, comparative and Logistic regression analyses were performed. RESULTS: We included 168 patients: 79.2% women, mean age 54.5 years (±13.2 SD), mean disease duration 7.5 years (±7.3 SD). Mean number of prior DMARD: 1.4 (±1.2 SD), mean number of prior BT was 0.8 (±1.1). Mean time on CZP was 9.8 months (±3.4 SD). A total of 71.4% were receiving CZP at 12-month assessment. Baseline predictors of response: lower prior number DMARD; low number prior BT; higher CRP, ESR, TJC, SJC, DAS28 and SDAI (p < 0.05) scores. A 25/46.4% Moderate/Good Response, a 20% SDAI remission, and a 44% DAS28 remission were observed. We observed 48 discontinuations (28.6%), 31 due to partial or complete ineffectiveness, and 17 due to side-effects. CONCLUSIONS: CZP showed benefit in severe RA patients, with significant reduction of all effectiveness parameters, despite the high prevalence of previous BT exposure in our series. We found CRP, ESR, prior DMARD/BT number, TJC, SJC, DAS28, and SDAI as baseline predictors of response. CZP was mostly well tolerated.
Assuntos
Hemoptise/etiologia , Neoplasias Pulmonares/complicações , Sarcoma Sinovial/complicações , Adulto , Neoplasias Encefálicas/secundário , Humanos , Neoplasias Pulmonares/diagnóstico , Neoplasias Pulmonares/cirurgia , Masculino , Pneumonectomia , Prognóstico , Sarcoma Sinovial/diagnóstico , Sarcoma Sinovial/secundário , Sarcoma Sinovial/cirurgiaRESUMO
No disponible
Assuntos
Humanos , Masculino , Adulto , Sarcoma Sinovial/patologia , Neoplasias Pulmonares/patologia , Hemoptise/etiologia , PneumonectomiaRESUMO
No disponible
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Hipotermia/complicações , Hipotermia/diagnóstico , Hipotermia/terapia , Serviços Médicos de Emergência/métodos , Temperatura Corporal/fisiologia , Eletrocardiografia , Insulina/uso terapêutico , Diabetes Mellitus/complicações , Escala de Coma de Glasgow/tendências , Escala de Coma de Glasgow , Cetoacidose Diabética/complicaçõesRESUMO
El síndrome de anticuerpos antifosfolipídicos catastrófico (SAAFC) es una forma rara de presentación del síndrome de anticuerpos antifosfolipídicos, de mal pronóstico, por lo que son necesarios un diagnóstico y un tratamiento precoces. Presentamos un paciente que tuvo gangrena como manifestación inicial de un SAAFC (AU)
Catastrophic antiphospholipid syndrome (CAPS) is an unusual form of presentation of antiphospholipid syndrome with a poor prognosis, so early diagnosis and treatment are necessary. We report a patient who had gangrene as the initial manifestation of CAPS (AU)
Assuntos
Humanos , Feminino , Adulto , Síndrome Antifosfolipídica/complicações , Gangrena/etiologia , Anticorpos Antifosfolipídeos/isolamento & purificação , Diagnóstico Precoce , Úlcera do Pé/etiologia , Glucocorticoides/uso terapêutico , Heparina de Baixo Peso Molecular/uso terapêutico , Transfusão de SangueRESUMO
No disponible
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Embolia Pulmonar/diagnóstico , Síncope/etiologia , Embolia Pulmonar/complicações , Doença Cardiopulmonar/complicaçõesRESUMO
Catastrophic antiphospholipid syndrome (CAPS) is an unusual form of presentation of antiphospholipid syndrome with a poor prognosis, so early diagnosis and treatment are necessary. We report a patient who had gangrene as the initial manifestation of CAPS.
RESUMO
El cuadro clínico de la endocarditis infecciosa es inespecífico. La fiebre y la auscultación de un soplo cardíaco son los síntomas más frecuentes. La asociación de artralgias es relativamente común, y es inusual la presentación en forma de poliartritis. Presentamos un caso de endocarditis infecciosa que se inicia con clínica subaguda de fiebre y poliartritis (AU)
Clinical signs of infective endocarditis are inespecific. Fever and heart murmur are the most frequent symptoms. Arthralgiass association is fairly common but presentation as polyarthritis is inusual. We report a cse of infective endocarditis that begins with subacute fever and polyarthritis (AU)
Assuntos
Humanos , Masculino , Adulto , Endocardite Bacteriana/complicações , Artrite/etiologia , Endocardite Bacteriana/diagnóstico , Febre/etiologia , Enterococcus faecalis/isolamento & purificação , Antibacterianos/uso terapêuticoRESUMO
La enfermedad cardiovascular es común en la artritis reumatoide. No obstante, la afección miocárdica es inusual y suele cursar de forma asintomática. Presentamos un caso de miocardiopatía dilatada en una paciente con artritis reumatoide e insuficiencia cardíaca progresiva que requirió su inclusión en lista de trasplante cardíaco (AU)
Cardiovascular pathology is common in rheumatoid arthritis. However, myocardial affection is unusual and clinical disease is rare. We report a case of dilated cardiomyopathy in a patient with rheumatoid arthritis and progressive heart failure that required inclusion into a heart transplantation list (AU)
Assuntos
Humanos , Cardiomiopatias/complicações , Artrite Reumatoide/complicações , Transplante de Coração , Listas de Espera , Insuficiência Cardíaca/complicações , Fator Reumatoide/isolamento & purificação , Cardiomiopatias/diagnósticoRESUMO
Cardiovascular pathology is common in rheumatoid arthritis. However, myocardial affection is unusual and clinical disease is rare. We report a case of dilated cardiomyopathy in a patient with rheumatoid arthritis and progressive heart failure that required inclusion into a heart transplantation list.
RESUMO
Clinical signs of infective endocarditis are inespecific. Fever and heart murmur are the most frequent symptoms. Arthralgias's association is fairly common but presentation as polyarthritis is inusual. We report a cse of infective endocarditis that begins with subacute fever and polyarthritis.