Prevalencia de síntomas neuropsiquiátricos en pacientes institucionalizados con diagnóstico de demencia y factores asociados: estudio transversal multicéntrico / Prevalence of neuropsychiatric symptoms and associated factors in institutionalised dementia patients: a multicentre cross-sectional study

Objetivo. El objetivo fue estimar la prevalencia y la gravedad de los síntomas neuropsiquiátricos en los pacientes con demencia ingresados en centros residenciales, evaluando su asociación con ciertos factores que podrían influir en su aparición. Material y métodos. Se realizó un estudio transversal. Se incluyeron todos los ancianos diagnosticados de demencia degenerativa, vascular o mixta, en estadios 4 a 7 de la Global Deterioration Scale de Reisberg (GDS), y residentes en 6 centros residenciales de la provincia de Ourense (España). Se calculó un tamaño de muestra de 120 individuos. La evaluación de los síntomas se realizó utilizando el Neuropsychiatric Inventory-Nursing Home (NPI-NH). La influencia de los factores considerados se analizó mediante el análisis de regresión lineal y logística. Resultados. Fueron incluidos 212 casos con una media de edad de 85,7 (6,7) años. La prevalencia de síntomas neuropsiquiátricos fue 84,4%. El síntoma más común fue la apatía, seguido por la agitación y el delirio; los menos frecuentes fueron la euforia y las alucinaciones. El síntoma que producía más interrupción ocupacional fue la agitación. El análisis multivariante mostró que una mayor puntuación en el NPI-NH estaba asociada con mayor puntuación en la escala GDS y el uso de neurolépticos, inhibidores de la colinesterasa y memantina. Conclusiones. En los pacientes con demencia institucionalizados los síntomas neuropsiquiátricos que presentan prevalencia elevada se asociaban con la gravedad de la demencia GDS, el uso de neurolépticos, inhibidores de la colinesterasa y memantina(AU)

Objective. The aim was to estimate the prevalence and severity of neuropsychiatric symptoms in patients with dementia in nursing homes, assessing their association with certain factors that may influence their occurrence. Material and methods. A cross-sectional study was carried out, and included all elderly patients diagnosed with degenerative, vascular, or mixed dementia, stage 4 to 7 on the Global Deterioration Scale of Reisberg (GDS), and residents in 6 nursing homes in the province of Ourense (Spain). A sample size of 120 individuals was determined to be necessary. The assessment of symptoms was performed using the Neuropsychiatric Inventory-Nursing Home test. The influence of the determined factors was investigated using logistic and linear regression analysis, and subsequently corrected for possible confounding factors. Results. A total of 212 cases were included, with a mean age of 85.7 (SD=6.7) years. The prevalence of neuropsychiatric symptoms was 84.4%. The most common symptom was apathy, followed by agitation and delirium, and the least frequent were euphoria and hallucinations. The symptom that produced most occupational disruption was agitation. Multivariate analysis showed that a higher score on the NPI-NH was associated with a higher score on the Global Deterioration Scale of Reisberg, the use of neuroleptics, cholinesterase inhibitors, and memantine. Conclusions. In nursing home patients, prevalence of neuropsychiatric symptoms was high, and associated with the severity of dementia (GDS), the use of neuroleptics, cholinesterase inhibitors, and memantine(AU)

[Prevalence of neuropsychiatric symptoms and associated factors in institutionalised dementia patients: A multicentre cross-sectional study]. / Prevalencia de síntomas neuropsiquiátricos en pacientes institucionalizados con diagnóstico de demencia y factores asociados: estudio transversal multicéntrico.

OBJECTIVE: The aim was to estimate the prevalence and severity of neuropsychiatric symptoms in patients with dementia in nursing homes, assessing their association with certain factors that may influence their occurrence. MATERIAL AND METHODS: A cross-sectional study was carried out, and included all elderly patients diagnosed with degenerative, vascular, or mixed dementia, stage 4 to 7 on the Global Deterioration Scale of Reisberg (GDS), and residents in 6 nursing homes in the province of Ourense (Spain). A sample size of 120 individuals was determined to be necessary. The assessment of symptoms was performed using the Neuropsychiatric Inventory-Nursing Home test. The influence of the determined factors was investigated using logistic and linear regression analysis, and subsequently corrected for possible confounding factors. RESULTS: A total of 212 cases were included, with a mean age of 85.7 (SD=6.7) years. The prevalence of neuropsychiatric symptoms was 84.4%. The most common symptom was apathy, followed by agitation and delirium, and the least frequent were euphoria and hallucinations. The symptom that produced most occupational disruption was agitation. Multivariate analysis showed that a higher score on the NPI-NH was associated with a higher score on the Global Deterioration Scale of Reisberg, the use of neuroleptics, cholinesterase inhibitors, and memantine. CONCLUSIONS: In nursing home patients, prevalence of neuropsychiatric symptoms was high, and associated with the severity of dementia (GDS), the use of neuroleptics, cholinesterase inhibitors, and memantine.