Experiencia del programa de atención integral a pacientes con pie diabético / Experiences of integral care program for patients with diabetic foot

La implantación y desarrollo del programa de atención integral a pacientes con pie diabético en nuestro centro, desde marzo del 2010 ha tenido resultados satisfactorios. El objetivo de nuestro trabajo investigativo fue evaluar el resultado de la administración intralesional del FCEH en las ulceras del pie diabético (UPD), para comprobar si facilitaba la granulación y cicatrización, y si al mismo tiempo disminuían las amputaciones. Se han incluido 73 pacientes con pie diabético, que fueron tratados con Heberprot –P. La totalidad de los pacientes que recibieron tratamiento presentaron lesiones clasificadas de grado 3 y 4 según la clasificación de Wagner, la evolución de estos pacientes fue satisfactoria (91,78% con granulación y cierre total de la lesión). Los pacientes amputados por el fracaso del tratamiento fueron el (8,21%). Se realizaron 73 intervenciones quirúrgicas en las que se acelero el proceso de cicatrización convirtiendo una herida crónica en aguda con la aplicación inmediata del Heberprot–P. La terapéutica fue mas efectiva en las ulceras isquemicas que en las neuropaticas, que son las de mayor riesgo de una amputación (AU)

The implementation and development of an integral program for patients with diabetic foot have had relevant results our center, during 2010.This work is aimed mainly at the evaluation of the results of the intralesional administration of hEGF in the diabetic foot ulcers, in terms of whether it facilitates granulation and cicatrisation or decreases the number of amputation. If included 73 patients who were treated with Heberprot-P, most patient’s lesions grade 3 and 4 based on Wagner’s classification, the evolution of the patient’s lesions was satisfactory ( with 91,78% of released patients) with granulation or total closure. Less than 10% of patients undergo an amputation because of treatment failure (with 8, 21%).A total of 73outpatient operations were performed in which post-surgical healing with the immediate use of Heberprot-P was accelerated and more effective. The therapy ischemic ulcers was effective which is the highest amputation risk (AU)

First autochthonous malaria case due to Plasmodium vivax since eradication, Spain, October 2010.

In October 2010, one case of autochthonous malaria due to Plasmodium vivax was diagnosed in Spain. The case occurred in Aragon, north-eastern Spain, where the vector Anopheles atroparvus is present. Although the source of infection could not be identified, this event highlights that sporadic autochthonous transmission of vector-borne diseases in continental Europe is possible and calls for enhanced surveillance and vector control measures.

Crude preparations of Dioon spinulosum dyer neurotoxicity: methylazoxymethanol produces petil mal seizures in susceptible individuals.

Dioon spinulosum is a cycad prepared as an alternative food and consumed by Chinantecos from Veracruz and Oaxaca, México. Whether Dioon spinulosum possesses neurotoxic properties is unknown, therefore, we used wistar rats receiving several regimens of D. spinulosum. Semi-liquid diarrhea followed the ingestion of crude kernels of D. spinulosum (group-1). In group-2 we offered during 10 days, purine and water during 12 h/day, and kernel or sclerotesta during the remaining 12 h (8.00 p.m. to 8.00 a.m.). As a result, a significantly decreased ingestion of water and cycad was compensated by a higher ingestion of purine and water during the period for which they had access to their normal diet. In group-3 which received lyophilized powdered crude kernel through a displaceable oesophagic cannula during 80 days, the locomotor activity was significantly lowered (p<0.05), but their fine motor ability for swimming remained unaltered. In this group, the computerized analysis of the electroencephalogram illustrated a dominance of high-voltage, high-frequency waves as compared to a matched-age control group (p<0.05). In group-4, the active toxin of cycads, methylazoxymethanol-glucoside applied directly to the cerebral cortex (1 µl), produced an epileptic status (spike-wave activity: 3-6 Hz/200 µV) lasting more than six hours in 30% of the animals. In conclusion, D. spinulosum produced a decrease in gross locomotor activity, and an increased excitability of the central nervous system.