RESUMO
A double-blind, randomized study was carried out on the side effects of disulfiram in 241 men and women with alcohol abuse. Of the 158 patients completing the study, 83 received disulfiram and 75 placebo. Each patient was questioned on side effects after a 2-week wash-out period and thereafter once a week during the 6-week treatment period.. There was no statistically significant difference between the two groups, apart from over-representation of complaints of sexual problems in the placebo group. The patients who dropped out of the study were equally distributed between the two groups with regard to the number, diagnosis, and reasons for dropping out.
Assuntos
Alcoolismo/reabilitação , Dissulfiram/efeitos adversos , Adulto , Ensaios Clínicos como Assunto , Dissulfiram/uso terapêutico , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeAssuntos
Admissão do Paciente , Unidade Hospitalar de Psiquiatria , Greve , Dinamarca , Feminino , Humanos , Masculino , MédicosRESUMO
A new antidepressant, amoxapine, which is a dibenzoxazepine deprivative, was compared with amitriptyline in a randomised double-blind trial. Forty-eight patients were included and 41 completed a 4-week treatment. Most of the patients were maintained on 150 mg daily. Assessments were made by the Hamilton Psychiatric Rating Scale for Depression (HAM-D), Nurses' Observation Scale for Inpatient Evaluation (NOSIE), Clinical Global Impression (CGI) scale and Patient's Self-Evaluation. The total HAM-D score was considerably reduced in the majority of the patients. Amitriptyline was the most effective with regard to symptoms included in the factor Sleep Disturbances and-secondary maybe-towards some items included in the factor Somatization. For the remaining items,including the items of the factors Anxiety/Depression and Apathy, the last score was lower in the amoxapine group than in those treated with amitriptyline. Among the unipolar cases the amoxapine treated patients were more satisfied with regard to efficacy (P = 6.3%). The frequency of side effects such as tremor and dizziness was considerably lower in the amoxapine group. In total, the side effects lasted longer in the amitriptyline group. We conclude that amoxapine seems to be an effective antidepressant with a low frequency of side effects.
