RESUMO
N-nitroso compounds are carcinogens that can be ingested directly or synthesized from nitrites and nitrates. The possible role of N-nitroso compounds in the induction of upper aerodigestive tract tumours was considered in a case-control study conducted in the Valle d'Aosta, an Italian region with a high incidence of these neoplasms. Nitrate, nitrite, labile and stable N-nitroso compounds were analysed in the saliva of 36 patients with cancers of the upper aerodigestive tract and 23 healthy individuals. After allowing for tobacco, salivary nitrate, nitrite and N-nitroso compounds were not associated with an increased risk of upper aerodigestive tract cancers. The odds ratio for continuous units of total N-nitros compounds was 0.99 (95% confidence interval 0.9-1.1). Thus, salivary nitrate, nitrite and N-nitroso compounds might not be suitable markers for the assessment of the risk of cancer of the upper aerodigestive tract, although a role for N-nitroso compounds cannot be excluded.
Assuntos
Neoplasias de Cabeça e Pescoço/etiologia , Nitratos/análise , Nitritos/análise , Compostos Nitrosos/análise , Fumar/efeitos adversos , Adulto , Idoso , Estudos de Casos e Controles , Intervalos de Confiança , Neoplasias de Cabeça e Pescoço/epidemiologia , Humanos , Incidência , Itália/epidemiologia , Masculino , Pessoa de Meia-Idade , Razão de Chances , Fatores de Risco , Saliva/química , Sensibilidade e EspecificidadeRESUMO
51 variously edentolous patients have been treated by placing 143 Core-Vent and Screw-Vent osteointegrated implants. The follow-up ranges from 8 to 20 months. Just one implant was removed. The Authors explain their surgical method and their considerations about the two different kinds of implants. Some clinical cases are reported.
Assuntos
Implantação Dentária Endóssea , Implantes Dentários , Adulto , Planejamento de Dentadura , Seguimentos , Humanos , Arcada Edêntula/reabilitação , Masculino , Pessoa de Meia-IdadeRESUMO
Serum and tonsillary tissue levels of cefroxadine, a new broad-spectrum cephalosporin, proving to be effective in several infections, particularly in the ENT ones, were measured in patients scheduled for tonsillectomy. Twenty patients (12 males, 8 females) aged between 11 and 25 years (mean 18.0 years) were given cefroxadine for 2 days (500 mg every 12 h), and on the 3rd day 500 mg of the drug was given before surgical operation. Tonsillar tissues were taken 2 h after dosing and blood samples before, 1, 2, 4 and 6 h after the drug administration in 8 out of 20 enrolled patients. Cefroxadine concentrations were measured according to microbiological methods. Cefroxadine tonsillary levels were 1.13 +/- 1.73 micrograms/g, approaching the MIC for sensitive bacteria. The time course of plasma levels is superimposable to previous studies. These findings suggest a rapid penetration of cefroxadine in tonsillar tissue and seem to confirm the clinical efficacy of the drug in ENT infections.
