RESUMO
OBJECTIVE: The study aim determined if low 25-hydroxy vitamin D levels correlated with low levels of adiponectin and insulin resistance in African American adolescents with body mass index > or = 85th %. PATIENTS AND METHODS: Fasting blood levels of adiponectin, 25-hydroxy vitamin D, insulin, glucose, lipid, leptin and glycosylated hemoglobin were measured in a total of 34 (19 study and 15 control) African American adolescents between the ages of 10 and 20 years. Nutritional vitamin D intake and body composition measurements were assessed. Insulin resistance was calculated using the homeostasis model assessment. RESULTS: Adiponectin, fasting insulin, glucose, leptin, triglycerides, HDL, and 25-hydroxy vitamin D levels all reached statistical significance in the group with body mass index > or = 85th percentile when compared to the control population. There was no difference in vitamin D intake between the two groups. CONCLUSIONS: Low vitamin D levels correlated with low adiponectin levels and obesity and insulin resistance.
Assuntos
Negro ou Afro-Americano , Resistência à Insulina , Obesidade/complicações , Obesidade/epidemiologia , Deficiência de Vitamina D/complicações , Deficiência de Vitamina D/epidemiologia , Adiponectina/sangue , Adolescente , Adulto , Negro ou Afro-Americano/estatística & dados numéricos , Estudos de Casos e Controles , Criança , Feminino , Humanos , Peso Corporal Ideal/fisiologia , Insulina/sangue , Resistência à Insulina/fisiologia , Leptina/sangue , Masculino , Estado Nutricional/fisiologia , Obesidade/sangue , Sobrepeso/sangue , Sobrepeso/complicações , Sobrepeso/epidemiologia , Vitamina D/análogos & derivados , Vitamina D/sangue , Deficiência de Vitamina D/sangue , Adulto JovemRESUMO
BACKGROUND: The pathophysiological role of thyroid-stimulating hormone (TSH) in the development of goiter is controversial. The aim of this study was to examine the relationship between thyroid nodularity and serum TSH levels in clinically and biochemically euthyroid patients with non-endemic multinodular goiter. METHODS: We surveyed 44 of our endocrine clinic patients with multinodular goiter. Twenty-five patients with suppressed TSH levels or positive antithyroid antibodies were excluded. The remaining 19 patients were included (group 1). The 19 study subjects were compared with 19 age- and sex- matched controls without any thyroid disease or goiter (group 2). TSH levels in both groups were checked by review of their medical records. RESULTS: In group 1, TSH ranged from 0.68-3.68 IU/mL (normal: 0.4-6.0 IU/mL), with a mean of 1.45 +/- 0.29. In group 2, TSH ranged from 0.38-1.88 IU/mL, with a mean of 1.08 +/- 0.1. The differences of these values, analyzed by paired t test (p=0.22), were not statistically significant. CONCLUSIONS: These data suggest that TSH levels in euthyroid patients with multinodular goiter are not significantly different from those in normal controls.
Assuntos
Bócio Nodular/sangue , Glândula Tireoide/fisiopatologia , Nódulo da Glândula Tireoide/sangue , Tireotropina/sangue , Estudos de Casos e Controles , Feminino , Bócio Nodular/etiologia , Humanos , Masculino , Estudos Retrospectivos , Testes de Função Tireóidea , Nódulo da Glândula Tireoide/etiologiaRESUMO
This case report describes a patient with pulmonary embolism (PE) in whom transesophageal echocardiography showed a thrombus in the right atrium attached to the eustachian valve (EV). The EV is typically absent in the adult, but when present it is considered to be benign. It is an uncommon site for thrombus formation. This patient was treated with systemic anticoagulation.
