[Malignant multifocal ENT tumors]. / Zlokachestvennye pervichno-mnozhestvennye opukholi LOR-organov.

Of 6787 patients with ENT cancer, multifocal tumors were detected in 319 cases (4.7%). 306(95.9%) patients had two tumors, 13(4.1%)--three tumors. Synchronous and metachroneous tumors were diagnosed in 39.2 and 60.8% patients, respectively. Primary tumors located more frequently in the larynx (n = 146) and pharynx (n = 50). The second tumors were more often found in the lungs (25.5%), pharynx (22.1%), oral cavity (13.2%). In 84.9% patients with multifocal tumors the first and the second lesions arose in the same organ system--respiratory and gastrointestinal tracts. Metachroneous tumors developed more often 2-5 years (49.1%) after cure of the primary tumor.

[The effect of local UHF hyperthermia and a fractionated radiation dosage on the incidence of perichondritis during the treatment of laryngeal cancer]. / Vliianie lokal'noi SVCh-gipertermii i fraktsionirovaniia dozy izlucheniia na chastotu perikhondritov pri lechenii raka gortani.

Perichondritis in patients treated by a continuous course were noted in 12.5 +/- 1.5%, in patients treated by a split method--in 4.6 +/- 1.2%, in chemoradiotherapy--in 5.75 +/- 1.3%, in thermoradiotherapy--in 3.0 +/- 2.9%, and after synchronization using 5-FU and large fractions--in 30.5 +/- 3.9%. Complications appeared mainly during the 1st year (85%), after 2-3 yrs.--in 8.4%, later on--in 6.6%. Local hyperthermia did not cause an increase in the number of complications.

[Reaction of the laryngeal mucosa and skin of the neck to the combined use of irradiation, hyperthermia and chemotherapy in laryngeal cancer]. / Reaktsii slizistoi obolochki gortani i kozhi shei pri kombinirovannom primenenii oblucheniia, gipertermii i khimioterapii raka gortani.

Reactions of the laryngeal and neck skin mucosa were studied in 93 laryngeal cancer patients on combined therapy including hyperthermia. Patients in the control groups received no local hyperthermia. Reactions on the laryngeal mucosa (hyperemia, insular and confluent epitheliitis) were observed in all the patients; in patients receiving chemotherapy they were more noticeable. In patients receiving local hyperthermia these reactions appeared somewhat later and were less noticeable and not repeated. Skin reactions correlated only with a radiation dose and did not depend on chemotherapy and hyperthermia. Local electromagnetic hyperthermia in laryngeal cancer patients neither influenced the appearance of radiation reactions nor enhanced them.