RESUMO
Approximately 8% of Caucasian males and 0.5% of females have congenital red-green color vision deficiencies (CVD), and a number of eye diseases are accompanied by acquired CVD. This feature issue includes ten contributions regarding existing and proposed algorithms and devices intended to help CVD subjects compensate for their color deficiencies. It also addresses limitations in the effectiveness of CVD aids for subjects with different types and degrees of color vision deficiency.
Assuntos
Doenças Cardiovasculares , Defeitos da Visão Cromática , Visão de Cores , Masculino , Feminino , Humanos , Defeitos da Visão Cromática/diagnóstico , Defeitos da Visão Cromática/terapia , Percepção de Cores , Testes de Percepção de Cores , Algoritmos , CorRESUMO
Color vision deficiency (CVD) has gained in relevance in the last decade, with a surge of proposals for aid systems that aim to improve the color discrimination capabilities of CVD subjects. This paper focuses on the proposal of a new metric called CVD-MET, that can evaluate the efficiency and naturalness of these systems through a set of images using a simulation of the subject's vision. In the simulation, the effect of chromatic adaptation is introduced via CIECAM02, which is relevant for the evaluation of passive aids (color filters). To demonstrate the potential of the CVD-MET, an evaluation of a representative set of passive and active aids is carried out both with conventional image quality metrics and with CVD-MET. The results suggest that the active aids (recoloration algorithms) are in general more efficient and produce more natural images, although the changes that are introduced do not shift the CVD's perception of the scene towards the normal observer's perception.
Assuntos
Doenças Cardiovasculares , Defeitos da Visão Cromática , Visão de Cores , Algoritmos , Cor , Percepção de Cores , Defeitos da Visão Cromática/diagnóstico , Simulação por Computador , Humanos , Visão OcularRESUMO
Grape aromatic characteristics are very important for producing quality wines. There have been very few studies on concentrations of volatile compounds in grape berries from vines with cover crops. For this reason, the aim of this work was to evaluate the influence of "Zulla" cover crop on the volatile profiles of organically grown Syrah variety grapes. For this purpose, volatile profiles of grapes obtained from vines with three different amounts of cover crop (one line, two lines, and four lines) and without cover crop, over three harvests (2019, 2020, and 2021) were determined. Moreover, a comparative study of conventional and organic crops, both submitted to soil tillage, was performed. The grape samples came from a warm climate zone. Must volatile compounds were determined by sequential sorptive extraction with Twisters by immersion (SBSE) and headspace (HSSE), followed by GC-MS analysis. A total of 160 compounds were determined and most of them were influenced by the presence of cover crop. However, the results showed an important influence of the harvest year over agronomic practices. Therefore, organic cultivation using Zulla cover crop seems to be a suitable tool for the implementation of friendly ecosystem management in a warm climate Syrah vineyard.
Assuntos
Vitis , Vinho , Ecossistema , Fazendas , Frutas , Vinho/análiseRESUMO
Yeasts can synthetise bioactive compounds such as Melatonin (MEL), Serotonin (SER) and Hydroxytyrosol (HT). Deciphering the mechanisms involved in their formation can lead to exploit this fact to increase the bioactive potential of fermented beverages. Quantitative analysis using labelled compounds, 15-N2 l-tryptophan and 13-C tyrosine, allowed tracking the formation of the above-mentioned bioactive compounds during the alcoholic fermentation of synthetic must by two different Saccharomyces cerevisiae strains. Labelled and unlabelled MEL, SER and HT were undoubtedly identified and quantified by High Resolution Mass Spectrometry (HRMS). Our results prove that there are at least two pathways involved in MEL biosynthesis by yeast. One starts with tryptophan as precursor being known for the vertebrates' pathway. Additionally, MEL is produced from SER which in turn is consistent with the plants' biosynthesis pathway. Concerning HT, it can be formed both from labelled tyrosine and from intermediates of the Erlich pathway.
Assuntos
Melatonina , Saccharomyces cerevisiae , Fermentação , Bebidas Fermentadas , Álcool Feniletílico/análogos & derivados , SerotoninaRESUMO
INTRODUCTION: Mild encephalitis/encephalopathy with a reversible isolated splenial corpus callosum lesion (MERS) is a clinical-radiological syndrome characterized by a lesion in the center of the splenium identified by magnetic resonance imaging (MRI), the imaging test of choice. CASE REPORT: A 31-year-old man is admitted with fever, intense hemicranial headache, disorientation, dysarthria and paresthesia in the lips and both upper extremities is presented; and that he is admitted for a suspected diagnosis of viral encephalitis. The cerebrospinal fluid analysis shows an elevation of proteins and the electroencephalogram shows generalized slowing, predominantly on the left. MRI shows a well-defined ovoid lesion, isolated in the splenium of the corpus callosum, homogeneous and hyperintense on T2 and FLAIR, with restriction to fluid diffusion and without uptake after gadolinium administration. The patient received empirical treatment with acyclovir and corticosteroids, with good subsequent evolution and disappearance of the lesion described in the control MRI at 3 weeks. CONCLUSION: MERS is a benign, infrequent entity of unknown pathogenesis, which must be differentiated from other pathologies that present with lesions of the corpus callosum, but with an unfavorable prognosis.
TITLE: Encefalitis/encefalopatía leve con lesión reversible del esplenio del cuerpo calloso (MERS).Introducción. La encefalitis/encefalopatía leve con lesión reversible aislada del esplenio del cuerpo calloso (MERS) es un síndrome clinicorradiológico caracterizado por una lesión en el centro del esplenio identificada por resonancia magnética, prueba de imagen de elección. Caso clínico. Se presenta el caso de un varón de 31 años con cuadro de fiebre, cefalea intensa hemicraneal, desorientación, disartria y parestesias en los labios y en ambas extremidades superiores, y que ingresa por sospecha diagnóstica de encefalitis vírica. El análisis del líquido cefalorraquídeo muestra una elevación de proteínas y el electroencefalograma manifiesta una lentificación generalizada de predominio izquierdo. La resonancia magnética evidencia una lesión ovoidea, bien delimitada, aislada en el esplenio del cuerpo calloso, homogénea e hiperintensa en T2 y FLAIR, con restricción a la difusión hídrica y sin captación tras la administración de gadolinio. El paciente recibe tratamiento de forma empírica con aciclovir y corticoesteroides, con buena evolución posterior y desaparición de la lesión descrita en la resonancia magnética de control a las tres semanas. Conclusión. La MERS es una entidad benigna, infrecuente y de patogenia desconocida, que debe diferenciarse de otras patologías que cursan con lesiones del cuerpo calloso en las que el pronóstico es desfavorable.
Assuntos
Encefalopatias/diagnóstico por imagem , Corpo Caloso , Encefalite/diagnóstico por imagem , Imageamento por Ressonância Magnética , Adulto , Humanos , Masculino , Índice de Gravidade de Doença , SíndromeRESUMO
Introducción: La encefalitis/encefalopatía leve con lesión reversible aislada del esplenio del cuerpo calloso (MERS) es un síndrome clinicorradiológico caracterizado por una lesión en el centro del esplenio identificada por resonancia magnética, prueba de imagen de elección. Caso clínico: Se presenta el caso de un varón de 31 años con cuadro de fiebre, cefalea intensa hemicraneal, desorientación, disartria y parestesias en los labios y en ambas extremidades superiores, y que ingresa por sospecha diagnóstica de encefalitis vírica. El análisis del líquido cefalorraquídeo muestra una elevación de proteínas y el electroencefalograma manifiesta una lentificación generalizada de predominio izquierdo. La resonancia magnética evidencia una lesión ovoidea, bien delimitada, aislada en el esplenio del cuerpo calloso, homogénea e hiperintensa en T2 y FLAIR, con restricción a la difusión hídrica y sin captación tras la administración de gadolinio. El paciente recibe tratamiento de forma empírica con aciclovir y corticoesteroides, con buena evolución posterior y desaparición de la lesión descrita en la resonancia magnética de control a las tres semanas. Conclusión: La MERS es una entidad benigna, infrecuente y de patogenia desconocida, que debe diferenciarse de otras patologías que cursan con lesiones del cuerpo calloso en las que el pronóstico es desfavorable.(AU)
Introduction: Mild encephalitis/encephalopathy with a reversible isolated splenial corpus callosum lesion (MERS) is a clinical-radiological syndrome characterized by a lesion in the center of the splenium identified by magnetic resonance imaging (MRI), the imaging test of choice. Case report: A 31-year-old man is admitted with fever, intense hemicranial headache, disorientation, dysarthria and paresthesia in the lips and both upper extremities is presented; and that he is admitted for a suspected diagnosis of viral encephalitis. The cerebrospinal fluid analysis shows an elevation of proteins and the electroencephalogram shows generalized slowing, predominantly on the left. MRI shows a well-defined ovoid lesion, isolated in the splenium of the corpus callosum, homogeneous and hyperintense on T2 and FLAIR, with restriction to fluid diffusion and without uptake after gadolinium administration. The patient received empirical treatment with acyclovir and corticosteroids, with good subsequent evolution and disappearance of the lesion described in the control MRI at 3 weeks. Conclusion: MERS is a benign, infrequent entity of unknown pathogenesis, which must be differentiated from other pathologies that present with lesions of the corpus callosum, but with an unfavorable prognosis.(AU)
Assuntos
Humanos , Masculino , Adulto , Encefalite/diagnóstico por imagem , Encefalopatias , Corpo Caloso , Índice de Gravidade de Doença , Cefaleia , Espectroscopia de Ressonância Magnética , Pacientes Internados , Exame Físico , Neurologia , Doenças do Sistema Nervoso , AciclovirRESUMO
Sherry white wine called Fino is produced by dynamic biological ageing under the action of flor yeasts using traditional practices aimed at ensuring uniform quality and characteristics over time. These kinds of yeasts provide typical sensory properties to Fino wines. Although there are studies of the volatile composition of these wines submitted to biological ageing in wood barrels, there is a lack of knowledge on the particular volatile profile produced by different flor yeast strains from Sherry zone wineries. For this reason, the aim of this study was to analyse the volatile profiles produced by 15 pure culture flor velum yeasts, with the goal of observing their suitability for obtaining high quality Fino sherry wines. Volatile composition was determined by dual sequential stir bar sorptive extraction, followed by GC-MS analysis. All yeast strains studied produced the increase of most acetals, highlighting acetaldehyde diethylacetal which was the compound that most increased. Among terpenes, nerolidol and farnesol underwent remarkable increases. However, results showed that in a month of biological ageing, significant differences were observed among the volatile metabolites produced by flor yeast strains studied. Only some of them stood out for their high production of volatile compounds characteristic of Sherry Fino wines, which are good candidates for producing starter cultures.
Assuntos
Qualidade dos Alimentos , Armazenamento de Alimentos/métodos , Odorantes/análise , Vinho/análise , Fermento Seco/metabolismo , Cromatografia Gasosa-Espectrometria de Massas , TempoRESUMO
This paper has studied the success of implantation for 16 commercial active dry yeasts (ADYs) during industrial fermentation (30) and the impact of these yeasts during spontaneous fermentations (19) in 10 wineries from the Denomination of Origin "Vinos de Madrid" over two consecutive years. Yeasts strains were identified by molecular techniques, pulsed field electrophoresis and microsatellite analysis. According to these techniques, all the ADYs were different with the exceptions of two strains, L2056 and Rh, which showed the same karyotype and loci size. The results showed that inoculating fermentations with ADYs did not ensure their dominance throughout the fermentation; the implantation level of ADYs was above 80% in only 9 of the 30 commercial fermentations studied; while in 16 fermentations, the dominance of the inoculated ADYs was below 50%. The type of vinification with the best implantation results overall were those associated with red wine fermentations. ADYs affected spontaneous fermentations, although their impact was observed to decrease in the second year of the study. Therefore, specific adaptation studies are necessary before using commercial yeasts during the fermentation process. At the same time, a study was carried out on the frequency of commercial strains in IMIDRA's yeast collection, made up of strains isolated from spontaneous fermentations of the different areas and cellars since the beginning of the Denomination of Origin "Vinos de Madrid" in 1990. Six different ADYs were found with a frequency of less than 5%.
RESUMO
Yeast nitrogen metabolism produces metabolites, whose origin in wines has scarcely been studied, with an important biological and organoleptic role. The present work focuses on comparing three intracellular extraction methods in order to elucidate efficiency of extraction while measuring the effect of temperature upon the integrity of the compounds related to the metabolism of tryptophan and tyrosine by yeast. Two UHPLC/HRMS methods to measure 16 metabolites were developed and validated. The validation provided optimum values of LOD (7.4·10-6 to 0.1⯵gâ¯L-1), of LOQ (2·10-5 to 0.02⯵gâ¯L-1) of precision (11-0.5% RSD) and repeatability (12-0.5% RSD). The removal of interfering molecules enabled matrix effects to be kept at low levels. The results pointed out that the low-temperature methods were more effective, providing better precision for 16 metabolites. The high-temperature extraction method may yield false enhanced compounds concentrations since they originate in cell wall macromolecules degradation.
Assuntos
Fracionamento Químico/métodos , Saccharomyces cerevisiae/metabolismo , Triptofano/análise , Tirosina/análise , Cromatografia Líquida de Alta Pressão , Temperatura Baixa , Congelamento , Glicerol/química , Espectrometria de Massas , Nitrogênio/metabolismo , Triptofano/metabolismo , Tirosina/metabolismo , Vinho/análiseRESUMO
The commercialization of EnChroma glasses has generated great expectations for people to be able to see new colors or even correct color vision deficiency (CVD). We evaluate the effectiveness of these glasses using two complementary strategies for the first time. The first consists of using the three classical types of tests - recognition, arrangement and discrimination - with and without glasses, with a high number of individuals. In the second, we use the spectral transmittance of the glasses to simulate the appearance of stimuli in a set of scenes for normal observers and observers with CVD. The results show that the glasses introduce a variation of the perceived color, but neither improve results in the diagnosis tests nor allow the observers with CVD to have a more normal color vision.
Assuntos
Defeitos da Visão Cromática/terapia , Visão de Cores/fisiologia , Óculos , Células Fotorreceptoras Retinianas Cones/fisiologia , Adolescente , Adulto , Percepção de Cores/fisiologia , Defeitos da Visão Cromática/fisiopatologia , Sensibilidades de Contraste , Desenho de Equipamento , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
Drug withdrawal-associated aversive memories trigger relapse to drug-seeking behavior. Corticotrophin-releasing factor (CRF) is an important mediator of the reinforcing properties of drugs of abuse. However, the involvement of CRF1 receptor (CRF1R) in aversive memory induced by opiate withdrawal has yet to be elucidated. We used the conditioned-place aversion (CPA) paradigm to evaluate the role of CRF1R on opiate withdrawal memory acquisition, along with plasticity-related processes that occur after CPA within the basolateral amygdala (BLA) and dentate gyrus (DG). Male mice were rendered dependent on morphine and injected acutely with naloxone before paired to confinement in a naloxone-associated compartment. The CPA scores as well as the number of TH-positive neurons (in the NTS-A2 noradrenergic cell group), and the expression of the transcription factors Arc and pCREB (in the BLA and DG) were measured with and without CRF1R blockade. Mice subjected to conditioned naloxone-induced morphine withdrawal robustly expressed CPA. Pre-treatment with the selective CRF1R antagonist CP-154,526 before naloxone conditioning session impaired morphine withdrawal-induced aversive memory acquisition. CP-154,526 also antagonized the enhanced number of TH-positive neurons in the NTS-A2 that was seen after CPA. Increased Arc expression and Arc-pCREB co-localization were seen in the BLA after CPA, which was not modified by CP-154,526. In the DG, CPA was accompanied by a decrease of Arc expression and no changes in Arc-pCREB co-localization, whereas pre-treatment with CP-154,526 induced an increase in both parameters. These results indicate that CRF-CRF1R pathway could be a critical factor governing opiate withdrawal memory storage and retrieval and might suggest a role for TH-NA pathway in the effects of withdrawal on memory. Our results might indicate that the blockade of CRF1R could represent a promising pharmacological treatment strategy approach for the attenuation of the relapse to drug-seeking/taking behavior triggered by opiate withdrawal-associated aversive memories.
Assuntos
Aprendizagem da Esquiva/efeitos dos fármacos , Complexo Nuclear Basolateral da Amígdala/efeitos dos fármacos , Condicionamento Psicológico/efeitos dos fármacos , Giro Denteado/metabolismo , Dependência de Morfina/metabolismo , Receptores de Hormônio Liberador da Corticotropina/metabolismo , Animais , Aprendizagem da Esquiva/fisiologia , Complexo Nuclear Basolateral da Amígdala/metabolismo , Condicionamento Psicológico/fisiologia , Hormônio Liberador da Corticotropina/metabolismo , Masculino , Memória/efeitos dos fármacos , Memória/fisiologia , Camundongos , Naloxona/farmacologia , Antagonistas de Entorpecentes/farmacologia , Neurônios/efeitos dos fármacos , Neurônios/metabolismo , Distribuição Aleatória , Comportamento Espacial/efeitos dos fármacos , Comportamento Espacial/fisiologiaRESUMO
Objetivos. La troponina de alta sensibilidad es un biomarcador de daño miocárdico que se asocia a un mayor riesgo de mortalidad y progresión de la enfermedad en pacientes con insuficiencia cardíaca aguda (ICA). Sin embargo, su relación con el riesgo de futuras rehospitalizaciones es menos conocido. El objetivo de este estudio fue evaluar la asociación entre los valores de troponina T ultrasensible (TnT-us) en pacientes con ICA y el riesgo de hospitalizaciones recurrentes en el seguimiento. Métodos. Se incluyó prospectivamente una cohorte de 621 pacientes consecutivos con ICA, excluyéndose pacientes con síndrome coronario agudo. Se determinó la TnT-us obtenida en el primer contacto médico en urgencias. El riesgo de reingresos acumulados se evaluó mediante regresión binomial negativa. Resultados. La edad media de los sujetos fue de 73,6±10,8 años, el 54,6% eran varones y el 52% tenían una función sistólica ventricular izquierda ≥50%. La mediana de TnT-us fue de 35,5pg/ml (rango intercuartílico [RI]=22-67). Tras una mediana de seguimiento de 1,2 años (RI= 0,4-2,4) se registraron 153 muertes (24,6%), 689 reingresos por todas las causas en 303 pacientes (48,8%), y 286 reingresos por IC en 163 pacientes (26,3%). En el análisis multivariante, los valores elevados de TnT-us se asociaron con un aumento del riesgo de reingreso, tanto por todas las causas como por IC (cociente de las tasas de incidencia [IRR] =1,16; intervalo de confianza del 95%, 1,02-1,36; p=0,029; IRR=1,23; intervalo de confianza del 95%, 1,04-1,46; p= 0,018, respectivamente). Conclusiones. En pacientes con ICA, el aumento de los valores de TnT-us se asoció de manera independiente con el riesgo de hospitalizaciones recurrentes durante el seguimiento (AU)
Objectives. High-sensitivity troponin is a biomarker of myocardial damage and is associated with a greater risk of mortality and disease progression in patients with acute heart failure (AHF). However, its relationship with the risk of future readmissions is less known. The aim of this study was to assess the association between ultrasensitive troponin T (TnT-us) values in patients with AHF and the risk of recurrent readmissions in the follow-up. Methods. We prospectively included a cohort of 621 consecutive patients with AHF, excluding those patients with acute coronary syndrome. We measured the TnT-us levels obtained during the first medical contact in the emergency department. The risk of cumulative readmissions was assessed using negative binomial regression. Results. The mean age of the participants was 73.6±10.8 years, 54.6% were men, and 52% had a left ventricular systolic function ≥50%. The median TnT-us level was 35.5pg/ml (interquartile range [IQR], 22-67). After a median follow-up of 1.2 years (IQR, 0.4-2.4), a total of 153 deaths (24.6%) were recorded, as well as 689 readmissions for all causes in 303 patients (48.8%) and 286 readmissions for HF in 163 patients (26.3%). In the multivariate analysis, the high TnT-us values were associated with an increased risk of readmission, both for all causes and for HF (incidence rate ratio [IRR], 1.16; 95% confidence interval, 1.02-1.36; p=.029 and IRR, 1.23; 95% confidence interval, 1.04-1.46; p=.018, respectively). Conclusions. For patients with AHF, the increase in TnT-us levels was independently associated with a risk of recurrent readmissions during the follow-up (AU)
Assuntos
Humanos , Masculino , Feminino , Idoso , Troponina T/efeitos adversos , Troponina T/análise , Insuficiência Cardíaca/complicações , Insuficiência Cardíaca/diagnóstico , Fatores de Risco , Recidiva , Insuficiência Cardíaca/mortalidade , Hospitalização/tendências , Estudos Prospectivos , Estudos de Coortes , Intervalos de Confiança , Análise Multivariada , 35170/métodosRESUMO
OBJECTIVES: High-sensitivity troponin is a biomarker of myocardial damage and is associated with a greater risk of mortality and disease progression in patients with acute heart failure (AHF). However, its relationship with the risk of future readmissions is less known. The aim of this study was to assess the association between ultrasensitive troponin T (TnT-us) values in patients with AHF and the risk of recurrent readmissions in the follow-up. METHODS: We prospectively included a cohort of 621 consecutive patients with AHF, excluding those patients with acute coronary syndrome. We measured the TnT-us levels obtained during the first medical contact in the emergency department. The risk of cumulative readmissions was assessed using negative binomial regression. RESULTS: The mean age of the participants was 73.6±10.8 years, 54.6% were men, and 52% had a left ventricular systolic function ≥50%. The median TnT-us level was 35.5pg/ml (interquartile range [IQR], 22-67). After a median follow-up of 1.2 years (IQR, 0.4-2.4), a total of 153 deaths (24.6%) were recorded, as well as 689 readmissions for all causes in 303 patients (48.8%) and 286 readmissions for HF in 163 patients (26.3%). In the multivariate analysis, the high TnT-us values were associated with an increased risk of readmission, both for all causes and for HF (incidence rate ratio [IRR], 1.16; 95% confidence interval, 1.02-1.36; p=.029 and IRR, 1.23; 95% confidence interval, 1.04-1.46; p=.018, respectively). CONCLUSIONS: For patients with AHF, the increase in TnT-us levels was independently associated with a risk of recurrent readmissions during the follow-up.
RESUMO
Melatonin is a neurohormone involved in the regulation of circadian rhythms in humans. Evidence has recently been found of its occurrence in wines and its role in the winemaking process. The yeast Saccharomyces cerevisiae is consequently thought to be important in Melatonin synthesis, but limited data and reference texts are available on this synthetic pathway. This paper aims to elucidate whether the synthetic pathway of Melatonin in Saccharomyces and non-Saccharomyces strains involves these intermediates. To this end, seven commercial strains comprising Saccharomyces cerevisiae (Red Fruit, ES488, Lalvin QA23, Uvaferm BC, and Lalvin ICV GRE) and non-Saccharomyces (Torulaspora delbrueckii and Metschnikowia pulcherrima) were monitored, under controlled fermentation conditions, in synthetic must, for seven days. Samples were analysed using a UHPLC-HRMS system (Qexactive). Five out of the seven strains formed Melatonin during the fermentation process: three S. cerevisiae strains and the two non-Saccharomyces. Additionally, other compounds derived from l-tryptophan occurred during fermentation.
Assuntos
Fermentação/fisiologia , Melatonina/metabolismo , Saccharomyces cerevisiae/metabolismo , Triptofano/metabolismo , Vinho , Aromatizantes/isolamento & purificação , Aromatizantes/metabolismo , Melatonina/isolamento & purificação , Saccharomyces/metabolismo , Triptofano/isolamento & purificação , Vinho/análiseRESUMO
No disponible
Assuntos
Humanos , Masculino , Pessoa de Meia-Idade , Morte Súbita Cardíaca , Exercício Físico , Atletismo , Anomalias dos Vasos Coronários/diagnóstico , Cateterismo Cardíaco , Reanimação Cardiopulmonar/métodosRESUMO
No disponible
Assuntos
Humanos , Masculino , Adulto , Morte Súbita Cardíaca/epidemiologia , Morte Súbita Cardíaca/patologia , Morte Súbita/etiologia , Morte Súbita/patologia , Fibrilação Ventricular/complicações , Fibrilação Ventricular , Nitratos/uso terapêutico , Poluição por Fumaça de Tabaco/efeitos adversos , Fumar/efeitos adversos , Transtornos Relacionados ao Uso de Substâncias/complicações , Eletrocardiografia/instrumentação , Estenose Aórtica Subvalvar , Vasoespasmo CoronárioAssuntos
Anomalias dos Vasos Coronários/complicações , Morte Súbita Cardíaca/etiologia , Corrida , Fibrilação Ventricular/terapia , Suporte Vital Cardíaco Avançado , Angiografia Coronária , Ponte de Artéria Coronária , Anomalias dos Vasos Coronários/diagnóstico por imagem , Anomalias dos Vasos Coronários/cirurgia , Técnicas de Diagnóstico Cardiovascular , Humanos , Imageamento Tridimensional , Masculino , Pessoa de Meia-Idade , Tomografia Computadorizada Multidetectores , Fibrilação Ventricular/complicaçõesRESUMO
OBJECTIVES: Obesity aggravates pelvic floor disorders in women. Weight loss improves these disorders. The purpose of this study was to assess the evolution of pelvic floor disorders in women who have undergone bariatric surgery. PATIENTS AND METHODS: A prospective single-center study was conducted from December 2012 to February 2014. The parameters studied were diabetes, BMI, excess weight loss, multiparity, mode of delivery and their relation to obesity and pelvic floor disorders. We evaluated anorectal and urethral sphincter disorders using the PFDI-20 questionnaire preoperatively, at 1 month and then every 6 months thereafter. RESULTS: One hundred and sixteen patients underwent bariatric surgery. Seventy questionnaires were completed preoperatively and postoperatively. Weight loss was significant with an excess weight loss of 57.1%. The mean body mass index (BMI) decreased from 44.5 ± 6.31 kg/m(2) (range: 35.0-63.23) to 31.83 ± 5.83 kg/m(2) (range: 20.9-49.6). The average length of follow-up was 11.3 ± 5.2 months (range: 5-25). The incidence of urinary symptoms improved after surgery (P=0.003), as did the UDI-6 score (Urogenital distress inventory) (P=0.009). There was no improvement in other symptoms such as prolapse and colorectal-anal dysfunction. CONCLUSION: The prevalence of pelvic floor disorders is high among obese women; in this study, colorectal disorders were present in 53% and urinary disorders in 71.5%. Bariatric surgery-induced weight loss led to improvement in urinary continence disorders when assessed over an average follow-up of 11 months.
Assuntos
Gastrectomia , Derivação Gástrica , Obesidade/cirurgia , Distúrbios do Assoalho Pélvico/complicações , Adulto , Idoso , Feminino , Seguimentos , Humanos , Pessoa de Meia-Idade , Obesidade/complicações , Distúrbios do Assoalho Pélvico/epidemiologia , Período Pós-Operatório , Prevalência , Estudos Prospectivos , Resultado do Tratamento , Redução de PesoRESUMO
No disponible