Multimodal Imaging Features of the Posterior Segment in Ocular Syphilis and HIV Co-Infection: A Single Center Case Series.

OBJECTIVE: To analyze the frequent multimodal imaging features in posterior syphilitic uveitis. PURPOSE: Syphilis infection has re-emerged as a global health problem. Multimodal imaging approach has been proposed for diagnosis and follow-up; there are not previous reports dedicated to the anatomic and visual outcomes in patients diagnosed with ocular syphilis and concomitant HIV infection. METHODS: All demographic information was recovered; a complete ophthalmological examination and multimodal imaging evaluation (retinal fluorescein angiography (FA), autofluorescence (AF), optical coherence tomography (OCT)) were performed on initial visit and 1 month after antibiotic therapy. RESULTS: 18 eyes of 9 patients were included. The most frequent features observed were: Hyperfluorescence on optic disk on FA, Hyperautofluorescence punctate pattern on AF, Vitritis on SD-OCT. After treatment, there was a functional and anatomical improvement. CONCLUSION: Ocular syphilis represents a diagnostic challenge. Multimodal imaging approach allows identification of structural changes, follow-up and early detection of complications.

[Peripheral and central audiologic findings in patients with Vogt-Koyanagi-Harada syndrome]. / Hallazgos audiológicos, periféricos y centrales en pacientes con síndrome de Vogt-Koyanagi-Harada.

OBJECTIVE: To identify and describe peripheral and central audiological abnormalities of patients with Vogt Koyanagi Harada syndrome. MATERIALS AND METHODS: Prospective, cross-sectional, observational, descriptive study. Vogt Koyanagi Harada patients referred from an ophthalmologic centre were assessed for signs and symptoms of auditory pathology. Peripheral audiological and central auditory processing tests were performed. To standardize the latter, methodological controls were matched for sex, age and audiometric chart. RESULTS: 21 patients were included (3 male, 18 female), mean age 40.7 years (+/-11.82). Nine of the 21 complained of tinnitus and nine suspected hearing loss. Exclusively or mainly sensorial abnormalities of pure tone audiometric chart were documented in 61.9% (mainly selective troughs at 4 and 8 kHz); 95.3% of patients had deficit in high-frequency audiometry. Five of the patients had sensorial disorders in the speech audiometry. No central auditory processing disorder was seen. CONCLUSIONS: Most of the patients with Vogt Koyanagi Harada syndrome had objective peripheral audiological abnormalities, although few revealed any symptoms.

Hallazgos audiológicos, periféricos y centrales en pacientes con síndrome de Vogt-Koyanagi-Harada / Peripheral and central audiologic findings in patients with Vogt-Koyanagi-Harada syndrome

Objetivo: Identificar y describir alteraciones audiológicas periféricas y centrales en pacientes con síndrome de Vogt-Koyanagi-Harada (VKH). Material y métodos: Estudio prospectivo, transversal, observacional y descriptivo. Buscamos en pacientes con VKH, referidos de centro oftalmológico, síntomas y signos de alteración audiológica y realizamos pruebas audiológicas periféricas y de procesos centrales de la audición (PCA). Para estandarizar estas últimas, utilizamos controles metodológicos pareados por edad, sexo y curva audiométrica. Resultados: Incluimos 21 pacientes (3 varones y 18 mujeres), edad promedio: 40,7 años (±11,82). Nueve de los 21 pacientes presentaron acúfeno y en 9 se sospechó hipoacusia. Documentamos alteración, exclusiva o mayoritariamente sensorial, de la audiometría convencional en el 61,9% (mayoritariamente caídas selectivas a 4 y 8kHz) y de altas frecuencias en el 95,3% de los pacientes. Cinco de los 21 pacientes presentaron alteraciones sensoriales de la logoaudiometría. No se concluyó alteración de PCA. Conclusiones: La mayoría de los pacientes con VKH presentaron alteraciones objetivas de la función auditiva periférica, aunque pocos manifestaron sintomatología (AU)

Objective: To identify and describe peripheral and central audiological abnormalities of patients with Vogt Koyanagi Harada syndrome. Materials and methods: Prospective, cross-sectional, observational, descriptive study. Vogt Koyanagi Harada patients referred from an ophthalmologic centre were assessed for signs and symptoms of auditory pathology. Peripheral audiological and central auditory processing tests were performed. To standardize the latter, methodological controls were matched for sex, age and audiometric chart. Results: 21 patients were included (3 male, 18 female), mean age 40.7 years (±11.82). Nine of the 21 complained of tinnitus and nine suspected hearing loss. Exclusively or mainly sensorial abnormalities of pure tone audiometric chart were documented in 61.9% (mainly selective troughs at 4 and 8kHz); 95.3% of patients had deficit in high-frequency audiometry. Five of the patients had sensorial disorders in the speech audiometry. No central auditory processing disorder was seen. Conclusions: Most of the patients with Vogt Koyanagi Harada syndrome had objective peripheral audiological abnormalities, although few revealed any symptoms (AU)