Observer-based control for plasma glucose regulation in type 1 diabetes mellitus patients with unknown input delay.

This article introduces an observer-based control strategy tailored for regulating plasma glucose in type 1 diabetes mellitus patients, addressing challenges like unknown time-varying delays and meal disturbances. This control strategy is based on an extended Bergman minimal model, a nonlinear glucose-insulin model to encompass unknown inputs, such as unplanned meals, exercise disturbances, or delays. The primary contribution lies in the design of an observer-based state feedback control in the presence of unknown long delays, which seeks to support and enhance the performance of the traditional artificial pancreas by considering realistic scenarios. The observer and control gains for the observer-based control are computed through linear matrix inequalities formulated from Lyapunov conditions that guarantee closed-loop stability. This design deploys a soft and gentle dynamic response, similar to a natural pancreas, despite meal disturbances and input delays. Numerical tests demonstrate the scheme's effectiveness in glycemic level regulation and hypoglycemic episode avoidance.

Pressure Sensor Placement for Leak Localization in Water Distribution Networks Using Information Theory.

This paper presents a method for optimal pressure sensor placement in water distribution networks using information theory. The criterion for selecting the network nodes where to place the pressure sensors was that they provide the most useful information for locating leaks in the network. Considering that the node pressures measured by the sensors can be correlated (mutual information), a subset of sensor nodes in the network was chosen. The relevance of information was maximized, and information redundancy was minimized simultaneously. The selection of the nodes where to place the sensors was performed on datasets of pressure changes caused by multiple leak scenarios, which were synthetically generated by simulation using the EPANET software application. In order to select the optimal subset of nodes, the candidate nodes were ranked using a heuristic algorithm with quadratic computational cost, which made it time-efficient compared to other sensor placement algorithms. The sensor placement algorithm was implemented in MATLAB and tested on the Hanoi network. It was verified by exhaustive analysis that the selected nodes were the best combination to place the sensors and detect leaks.