RESUMO
In the gingival crevicular fluid (GCF) of control and chronic adult periodontitis (CAP) patients there is a spontaneous release of O2- radicals from polymorphonuclear leukocytes (PMN). The addition of the exogenous stimuli phorbol myristate acetate (PMA) decreased the O2-. formation in control GCF, while in CAP patients produced a marked enhancement of O2-. generation. The circulating PMN of control subjects did not show a spontaneous O2-. formation, differently from CAP patients. On the contrary, a similar O2-. production was measured when the circulating PMN were stimulated with PMA. Moreover, the antioxidant activity measured in 10 microliters of cell free gingival supernatant (GS) of control and CAP patients had the same values by inhibiting 12.6% and 18.9% respectively of the O2- formation supported by a xanthine/xanthine oxidase system. Probably, the protective or destructive effect of PMN in GCF of CAP patients depends on the variations of the rate of O2- formation in respect to the intrinsic antioxidant property of GS.
Assuntos
Líquidos Corporais/química , Gengiva , Neutrófilos/metabolismo , Oxigênio/metabolismo , Periodontite/patologia , Explosão Respiratória , Superóxidos/metabolismo , Adulto , Doença Crônica , Sequestradores de Radicais Livres , Radicais Livres , Humanos , Neutrófilos/efeitos dos fármacos , Neutrófilos/patologia , Oxirredução , Periodontite/metabolismo , Explosão Respiratória/efeitos dos fármacos , Acetato de Tetradecanoilforbol/farmacologiaRESUMO
The initial phases of the embryogenetic process are evaluated in order to define its mesenchymal matrix. The influence of cephalic neural crests on mesenchymal derivatives is also underlined. Finally paraxial and lateral mesodermal function on cranial development and brachial arches composition are described. A correlation is established between head and neck, neural crests, mixed and sensorial cranial nerves. Tongue and orbital cavity muscles are identified as paraxial matrix derivative organs.
Assuntos
Região Branquial/embriologia , Face/embriologia , Boca/embriologia , Nervos Cranianos/embriologia , Cabeça/embriologia , Humanos , Mesoderma , Morfogênese , Crista Neural/embriologiaRESUMO
The Authors give a detailed analysis of the potential virulence factors and possible pathogenic processes associated with candida. They qualify the interactions between local, general, natural and acquired defences, setting out the possible deficiency involved in the emergence of secondary candidiasis. They make a classificatory revision of forms of candidiasis on the basis of topographic, anatomo-pathologic criteria and of the course of the disease. They investigate the most significant aspects of the situations described especially in oral localization. An evaluation is made of chronic mucocutaneous candidiasis as a pathological affection in itself and in its correlation with H.I.V. infection.
Assuntos
Candida , Candidíase Bucal , Síndrome da Imunodeficiência Adquirida/complicações , Candida/imunologia , Candida/patogenicidade , Candida/fisiologia , Candidíase Bucal/classificação , Candidíase Bucal/etiologia , Candidíase Bucal/imunologia , Candidíase Bucal/microbiologia , Humanos , ImunidadeRESUMO
The classification, pathogenesis, clinical features and treatment of pemphigus are examined with emphasis' on the histopathological similarities of the elementary intraepithelial lesion and the histotopographical differences at epithelial level that differentiate the various types of pemphigus. In a detailed review of the pathogenesis of the condition, the circumstances propitious for the onset of pemphigus are identified as an HLA phenotype and the autoantigenic denaturation of the glycocalyx. The condition is described as vesicolobullous and is differentiated from similar bullous and non-bullous dermatoses. The most significant pictures of oral pemphigus are specified as are the basic elements of general and local treatment.
