Dynamics of Structural Parameters and Accumulation of Collagen Fibrils in Rat Lung after Inhalations of Surfactant-BL at Various Terms of Bleomycin-Induced Alveolitis.

Rats were subjected to surfactant-BL inhalations at the early and late phases of bleomycininduced alveolitis. In both regimens, the drug reduced the severity of inflammation. In the acute phase of alveolitis, the therapeutic effect of inhalation was accompanied by activation of the synthesis of fine lose collagen fibrils. In the late phase of alveolitis, inhalation of surfactant-BL thickened the fibrils and diminished their population in alveolar walls.

Effectiveness of correction of bleomycin-induced lung injury by early and late administration of surfactant-BL.

Rats were exposed to inhalation of surfactant-BL starting from the first or eighth day after intratracheal administration of bleomycin. At the early stages, the preparation effectively attenuated damage to ultrastructural components of the lung tissue and reduced the severity and extent of subsequent pulmonary pathology.

[Results of modified radiotherapy in the treatment of patients with uterine cancer]. / Rezultaty modifitsirovannoi luchevoi terapii bolnykh rakom matki.

A ten year experience gained in radiotherapy with radio modifiers of 480 patients with cancer of the cervix uteri and of 189 ones with endometrial cancer carried out at the Central Research Roentgeno-Radiological Institute of the Russian Academy of Medical Sciences is analyzed. Local administration of metromidasole with dimethysulfoxide essentially enhanced the detrimental effect of radiation on the tumor. This is reflected in a higher incidence of local control in radiotherapy of patients with cancer of the cervix and corpus uteri. A reduced incidence and degree of radiation injury to organs adjacent to the uterus was observed.