RESUMO
The International Society for Stem Cell Research (ISSCR) task force that developed new Guidelines for the Clinical Translation of Stem Cells discusses core principles that should guide the responsible transition of basic stem cell research into appropriate clinical applications.
Assuntos
Tecnologia Biomédica/normas , Terapia Baseada em Transplante de Células e Tecidos/normas , Ensaios Clínicos como Assunto/normas , Guias de Prática Clínica como Assunto/normas , Transplante de Células-Tronco/normas , Animais , Tecnologia Biomédica/ética , Terapia Baseada em Transplante de Células e Tecidos/ética , Comitês de Monitoramento de Dados de Ensaios Clínicos/normas , Ensaios Clínicos como Assunto/ética , Humanos , Consentimento Livre e Esclarecido/normas , Monitorização Fisiológica/normas , Revisão por Pares/normas , Transplante de Células-Tronco/éticaRESUMO
Embryonic implantation, the process by which the human embryo orientates towards, attaches to and finally invades the underlying maternal endometrial tissue, requires a receptive endometrium, a functionally normal blastocyst and an adequate cross-communication between them. During apposition, human blastocysts find a location in which to implant, while they are guided to a specific area in the maternal endometrium. In the adhesion phase, which occurs 6 to 7 days after ovulation, within the so-called "implantation window", direct contact occurs between the endometrial epithelium (EE) and the trophectoderm (TE). Finally, in the invasion phase, the embryonic trophoblast traverses the basement membrane and passes the endometrial stroma and reaches the uterine vessels. Many molecules (hormones, cytokines, integrins, enzymes, etc.) take part in the dialogue between the human blastocyst and the maternal endometrium to achieve implantation. Here, we present our published data on the embryonic regulation of endometrial epithelial molecules such as chemokine receptors and the leptin system.