1.
Bioorg Med Chem Lett
; 13(19): 3277-80, 2003 Oct 06.
Artigo
em Inglês
| MEDLINE
| ID: mdl-12951108
RESUMO
A series of substituted naphthyl containing chiral [2.2.1] bicycloheptanes were prepared utilizing asymmetric Diels-Alder chemistry. This paper describes structure-activity relationships in this series. The N-methyl 2-naphthyl analogue (16d) and its des-methyl analogue (17d) are active triple re-uptake inhibitors both in vivo and in vitro.