1.
Org Biomol Chem
; 16(8): 1242-1246, 2018 02 21.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29379930
RESUMO
A 3-step methodology for the synthesis of 1,5-benzothiazepin-4(5H)-one dipeptidomimetics has been elaborated via an Ugi-4CR followed by a S-trityl deprotection and an intramolecular Cu(i)-catalyzed Ullmann condensation with moderate to good yields. In silico and NMR conformational studies showed that the lowest energy conformers stabilize γ- and ß-turn structures.