[The gastroduodenal peptic ulcerous disease (author's transl)]. / La maladie ulcéreuse gastroduodénale

After a brief history of gastroduodenal ulcer since the 19th century, the authors discuss the question of its uniqueness. Upon clinical, biological and genetic grounds, it seems possible to distinguish two different kinds of ulcers. Ulcers situated above the junction between fundic and antropyloric mucosae could possibly be the consequence of biliary reflux, while ulcers situated below this junction would be associated with hyperchlorhydria. Some properties of gastrin, which is responsible for Zollinger-Ellison syndromes I and II, are cited. Presently, gastrin cannot be considered as the primary cause of duodenal ulcer.

Limits of the evocative pancreatic function test in the diagnosis of low-grade pancreatitis.

At a certain level of stimulation of the enzymatic secretions of the pancreas utilizing duodenal hormones and caerulein in normal subjects, the hourly urinary amylase output increases beyond normal values. Under these conditions, the so-called evocative pancreatic function test becomes unusable for the diagnosis of chronic pancreatitis in the early stages.