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Front Immunol ; 10: 2970, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31921208

RESUMO

The CXCL12-CXCR4 axis plays a key role in the retention of stem cells and progenitors in dedicated bone marrow niches. It is well-known that CXCR4 responsiveness in B lymphocytes decreases dramatically during the final stages of their development in the bone marrow. However, the molecular mechanism underlying this regulation and whether it plays a role in B-cell homeostasis remain unknown. In the present study, we show that the differentiation of pre-B cells into immature and mature B cells is accompanied by modifications to the relative expression of chemokine receptors, with a two-fold downregulation of CXCR4 and upregulation of CCR7. We demonstrate that expression of CCR7 in B cells is involved in the selective inactivation of CXCR4, and that mature B cells from CCR7-/- mice display higher responsiveness to CXCL12 and improved retention in the bone marrow. We also provide molecular evidence supporting a model in which upregulation of CCR7 favors the formation of CXCR4-CCR7 heteromers, wherein CXCR4 is selectively impaired in its ability to activate certain G-protein complexes. Collectively, our results demonstrate that CCR7 behaves as a novel selective endogenous allosteric modulator of CXCR4.


Assuntos
Medula Óssea/imunologia , Diferenciação Celular/imunologia , Células Precursoras de Linfócitos B/imunologia , Receptores CCR7/imunologia , Receptores CXCR4/imunologia , Animais , Diferenciação Celular/genética , Quimiocina CXCL12/genética , Quimiocina CXCL12/imunologia , Camundongos , Camundongos Knockout , Células Precursoras de Linfócitos B/citologia , Receptores CCR7/genética , Receptores CXCR4/genética
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