RESUMO
Is atmospheric dispersion forecasting an important asset of the early-phase nuclear emergency response management? Is there a 'perfect atmospheric dispersion model'? Is there a way to make the results of dispersion models more reliable and trustworthy? While seeking to answer these questions the multi-model ensemble dispersion forecast system ENSEMBLE will be presented.
Assuntos
Poluentes Radioativos do Ar/análise , Planejamento em Desastres/métodos , Modelos Teóricos , Proteção Radiológica/métodos , Cinza Radioativa/análise , Radiometria/métodos , Gestão da Segurança/métodos , Movimentos do Ar , Simulação por Computador , Sistemas de Apoio a Decisões Administrativas/organização & administração , Planejamento em Desastres/organização & administração , Emergências , Monitoramento Ambiental/métodos , Europa (Continente) , Previsões , Cooperação Internacional , Centrais Elétricas , Doses de Radiação , Liberação Nociva de Radioativos , Medição de Risco/métodos , Fatores de Risco , Gestão da Segurança/organização & administraçãoRESUMO
N-methyl- alpha -benzyl-o-aminomethylphenylacetic acid was incorporated into a cyclic somatostatin analogue in order to mimic a cis-peptide bond configuration. The high biological potency of one of the isomers of the cyclic peptide strongly argues in favour of the proposed cis-configuration of the peptide bond at that position in the parent peptide. This represents the first cis-peptide bond mimic which has high biological activity.
Assuntos
Somatostatina/análogos & derivados , Animais , Hormônio Liberador de Gonadotropina/farmacologia , Hormônio do Crescimento/metabolismo , Isomerismo , Hipófise/efeitos dos fármacos , Conformação Proteica , RatosRESUMO
The stereochemical purity of psi (CH2-NH) dipeptides has been determined using gas chromatography-mass spectrometry. Different structures were found due to the derivatization procedures. A selective preparation of the linear bistrifluoroacetylated derivative and the monotrifluoroacetylated lactam makes it possible to monitor the chiral purity of the pseudodipeptides synthesized. Racemization occurring during peptide hydrolysis can be differentiated from racemization during the synthesis by using deuterium labelling. The method allows the optimization of the synthesis protocols and will be useful for further monitoring of the chiral purity of the pseudopeptides synthesized.
