1.
Arch Int Pharmacodyn Ther
; 251(2): 228-36, 1981 Jun.
Artigo
em Inglês
| MEDLINE
| ID: mdl-7197142
RESUMO
The effects of withdrawal from chronic ethanol administration on locomotion and rearing frequencies of rats and mice were studied. Ethanol withdrawal induced a significant increase in animal's activity. In mice a positive correlation was found between locomotion plus rearing frequencies and audiogenic-induced seizures susceptibility 25 hr after ethanol removal. Results show that general activity evaluated through the open-field method might be used as a simple, non-drastic and reliable procedure to detect ethanol withdrawal symptoms in laboratory animals.