RESUMO
INTRODUCTION: Photodynamic therapy is an innovative treatment modality, which is appropriate for tumor detection and for the treatment of cancer as well as nontumoral diseases, such as psoriasis (2), bacterial and viral eradication. MATERIAL AND METHOD: Effect of two photosensitizer (toluidine blue O (TBO) and Radachlorin was investigated on Staphylococcus Aureus ATCC 25923 (American Type Culture Collection) and Escherichia coli (ATCC 25922). RESULTS: PDI by TBO caused S. aureus 5.83 log10 killing (P.Value<0.0001) and reduce 0.08 log 10 in E. coli (P.Value=0.321). PDI by Radachlorin(®) reduce 0.17 log 10 in E. coli (P.Value<0.0001) and S. aureus showed 6.1 log 10 colony count reduction. CONCLUSION: Within the limitation of this in vitro study, we can conclude that both PS have the same effect on S. aureus and E. coli with good inhibition effect on S. aureus and partial inhibition effect E. coli.
