Time course study of Paenarthrobacter nicotinovorans secondary metabolite toxicity profile.

In previous studies , Paenarthrobacter nicotinovorans was isolated and screened for antimicrobial activity. Further, secondary metabolites were isolated and screened for antimicrobial activity and cytotoxicity in vitro . The current study determines if increased exposure of Hela cells to the secondary metabolites over time increases the cytotoxicity. The results show no detectable increase of cytotoxicity in HeLa cells.

Toxicity of secondary metabolites of Paenarthrobacter nicotinovorans.

In a previous study, Paenarthrobacter nicotinovorans was isolated and screened for antimicrobial activity. Many promising antibiotic candidates are not ultimately used because of toxicity. After screening secondary metabolites for antimicrobial activity, they were screened for cytotoxicity in vitro in the human HeLa cell line. The results show that there is no detectable cytotoxicity in HeLa cells.

Antimicrobial activity of Paenarthrobacter nicotinovorans.

Antibiotic resistance is one of the biggest global challenges of the century. Many pathogens have become resistant to antibiotics due to human misuse and effective ones are in short supply. Discovering potential new antibiotic molecules may help to address the current antibiotic shortage. To this end, the Tiny Earth program, which engages students from around the world to discover potential antibiotic producing microbes from the local soil, was utilized. Students collect, screen, and isolate bacteria from their local communities in hopes of addressing the global crisis of antibiotic resistance. One such microbe, Paenarthrobacter nicotinovorans , was isolated and screened for antimicrobial activity.