1.
Trends Biochem Sci
; 25(9): 419-21, 2000 Sep.
Artigo
em Inglês
| MEDLINE
| ID: mdl-10973052
RESUMO
The amino acid sequences of enzymes like alcohol dehydrogenase and glyceraldehyde-3-phosphate dehydrogenase are strongly conserved across all phyla. We suggest that the amino acid conservation of such enzymes might be a result of the fact that they function as part of a multi-enzyme complex. The specific interactions between the proteins involved would hinder evolutionary change of their surfaces.