Hypertrophic osteoarthropathy associated with Pneumocystis carinii pneumonia in AIDS.

Hypertrophic osteoarthropathy (HOA) is a systemic disorder primarily affecting the bones, joints, and soft tissues and developing in association with another disease process. Acute pyogenic pulmonary processes (empyema, lung abscess) are occasionally accompanied by transient HOA, but reversible HOA has not previously been reported in the setting of PCP in AIDS.

Attempts at clarification of splenic visualization on reticuloendothelial images: Tc-99m DISIDA compared with heat- denatured Tc-99m RBC imaging.

Four patients with enlarged left hepatic lobes and questionable or difficult splenic visualization on Tc-99m sulphur colloid (SC) images were further examined with additional radionuclide procedures. All four patients had Tc-99m DISIDA imaging, and three of them also had heat-denatured Tc-99m RBC imaging. The hepatobiliary images appear very effective in confirming postsplenectomy expanded enlargement of the left lobe of the liver and in refuting the presence of spleen in such cases. However, distinct visualization of the spleen in these patients can be achieved only through selective spleen imaging with heat-damaged red cells.

Reversible pulmonary uptake and hypertrophic pulmonary osteoarthropathic distribution of technetium-99m methylene diphosphonate in a case of Pneumocystis carinii pneumonia.

Diffuse pulmonary deposition of [99mTc]methylene diphosphonate (MDP) as well as abnormalities characteristic of hypertrophic pulmonary osteoarthropathy have been observed in a patient with Pneumocystis carinii pneumonia (PCP). The findings of the bone scan together with those in the corresponding scintigraphy, and roentgenograms of the chest and skeletal structures are presented. Parallel reversal of [67Ga]citrate and [99mTc]MDP pulmonary uptake with specific treatment for and clinical resolution of PCP implies a causal relationship.

Paget's disease: a cause of photopenic skeletal defect in indium-111 WBC scintigraphy.

As an incidental finding in an [111In]WBC scan performed in search of an infectious focus, photon deficient areas were found in several skeletal locations, characterized by bone and gallium scintigraphy and confirmed radiographically as sites of active Paget's disease. The literature concerning cold bone defects in the [111In]WBC scintiscan is reviewed. Loss of marrow component in the bone appears to be the underlying mechanism for such an abnormality.