GSK-3 kinase a putative therapeutic target in trypanosomatid parasites.

Trypanosomatids are an important group of parasites that predominate in tropical and subtropical areas of the planet, which cause diseases that are classified as forgotten and neglected by the world health organization. In this group of parasites, we find Trypanosoma cruzi, Trypanosoma brucei, Trypanosoma brucei rhodesiense and Leishmania spp, for which there is no vaccine available, and its control has focused mainly on pharmacological treatment. Due to the poverty situation where these diseases are found and the biological complexity of these parasites, there are multiple variables to control, including the diversity of species, the complexity of their life cycles, drug resistance, cytotoxicity, the limited use in pregnant women, the high costs of treatment and the little-known pharmacological mechanisms of action, among others. It is therefore necessary to find new strategies and approaches for the treatment of these parasitic diseases. Among these new approaches is the rational search for new targets based on the allosteric inhibition of protein kinases, which have been little studied in trypanosomatids. Among these kinases, we find Glycogen Synthase Kinase-3 (GSK-3), a kinase of great pharmacological interest, which is under intense basic and clinical research by pharmaceutical companies for the treatment of cancer. This kinase, highly studied in the PI3K/AKT/mTOR pathway signaling in humans, has an orthologous gene in these parasites (GSK-3 s), which has proven to be essential for them in response to different challenges; Therefore, it is notable to increase research in this kinase in order to achieve a broad structural and functional characterization in the different species of trypanosomatids.

Alergia a medicamentos. / Drug allergy

En el presente articulo se efectua una exaustiva revision de este importante capitulo de la alergia. Se discuten en esta revision de un modo completo los mecanismos etiopatogenicos de la alergia a medicamentos ubicando los diferentes mecanismos de produccion de la misma dentro del modelo de Gell y Coombs. Se tratan asimismo con gran detalle los elementos del diagnostico de esta entidad remarcando los elementos de diagnostico diferencial con otros cuadros alergicos a traves de diferentes pruebas de reactividad alergica a drogas. Por ultimo, se describen las modalidades terapeuticas dependientes de la intensidad de los sintomas y la naturaleza del alergeno desencadenante, enfatizando los limites y posibilidades de las tecnicas de desensibilizacion