The Improvement of Nonspecific Chronic Symptoms Post-Gallbladder Clip Removal.

Laparoscopic cholecystectomy is the first line of treatment for patients with symptomatic gallstones. Surgical clips made of stainless steel are still used by surgeons during these laparoscopic procedures and are considered relatively safe. These surgical clips, however, have been linked to severe side effects, including weight loss, dermatitis, angioedema, sleep hyperhidrosis, and more. This report documents the case of a 71-year-old female who presented for the removal of surgical stainless steel clips post-cholecystectomy after 16 years of chronic manifestations, including rashes on the torso and breasts, hives, weight loss, chills, and neuropathy due to a previously undiagnosed nickel allergy.