Assuntos
Governo Federal , Apoio à Pesquisa como Assunto/legislação & jurisprudência , Ciência/economia , Orçamentos , Investimentos em Saúde , México , Seleção de Pessoal , Apoio à Pesquisa como Assunto/economia , Ciência/legislação & jurisprudência , Ciência/normas , Tecnologia/economia , Recursos HumanosAssuntos
Alphapapillomavirus/imunologia , Suscetibilidade a Doenças , Infecções por Papillomavirus/imunologia , Infecções por Papillomavirus/patologia , Neoplasias do Colo do Útero/diagnóstico , Neoplasias do Colo do Útero/epidemiologia , Alphapapillomavirus/genética , Alphapapillomavirus/isolamento & purificação , Alphapapillomavirus/patogenicidade , Biomarcadores/análise , Progressão da Doença , Suscetibilidade a Doenças/imunologia , Feminino , Humanos , Evasão da Resposta Imune/imunologia , Infecções por Papillomavirus/diagnóstico , Infecções por Papillomavirus/epidemiologia , Vacinas contra Papillomavirus/administração & dosagem , Neoplasias do Colo do Útero/imunologia , Neoplasias do Colo do Útero/virologia , Carga Viral , Latência Viral/imunologiaRESUMO
In April this year, a new influenza virus of swine origin emerged in Mexico and spread rapidly around the world. As the Northern hemisphere winter flu season kicks off, Laura Vargas-Parada reports on the measures that Mexico is taking to combat the H1N1 pandemic.
Assuntos
Surtos de Doenças , Influenza Humana/epidemiologia , Defesa Civil , Humanos , Vírus da Influenza A Subtipo H1N1 , Vacinas contra Influenza/provisão & distribuição , Influenza Humana/diagnóstico , Influenza Humana/prevenção & controle , México/epidemiologiaRESUMO
In Mexico informed consent is a legal requirement that ensures that patients who are invited to participate in clinical trials are provided with all the information needed to decide whether to participate, or not, in a research protocol. To improve our understanding of the problems physicians in developing countries encounter, when obtaining informed consent (IC), we examined their opinion on the importance of IC in clinical research, the quantity and quality of the information provided to the participant, and the conditions in which the IC is obtained. Investigators considered that IC was useful to the patients, providing information that helped the patient to make a decision about his/her participation. Nevertheless, they felt that for some aspects of the research, like drug development in general, the use of placebos, and the randomization process, many of the patients were not capable of fully understanding the information provided, referring to the complexity of the information and illiteracy as the main reasons. Many investigators were not acquainted with some of the guidelines established in the Mexican General Law of Health,(1) 36% of them admitting to not having completed their IC letters. Most investigators gave only minutes to the patient to make a decision and 20% of ICs were obtained while the patient was hospitalized. Except for one investigator, all of them considered that specific training in medical ethics would be useful for the daily clinical work.
Assuntos
Atitude , Ensaios Clínicos como Assunto , Consentimento Livre e Esclarecido , Pesquisadores/psicologia , Ensaios Clínicos como Assunto/ética , Ensaios Clínicos como Assunto/normas , Compreensão , Revelação/ética , Revelação/normas , Ética Médica/educação , Humanos , Consentimento Livre e Esclarecido/psicologia , Consentimento Livre e Esclarecido/estatística & dados numéricos , México , Relações Médico-Paciente , Projetos de Pesquisa , Sujeitos da Pesquisa , Medição de RiscoRESUMO
Paramyosin is a muscle protein that probably plays a role in the survival of the larval stage of Taenia solium during its prolonged host-parasite relationship. Here we describe the structure of the gene coding for the paramyosin of T. solium. The characterization of two clones obtained from a genomic library showed that the complete gene of paramyosin contains 13 introns delimited by conventional eukaryotic splice signals. Comparison with the paramyosin genes of Drosophila melanogaster and Caenorhabditis elegans showed a lack of conservation of the exon/intron organization in contrast to other muscle genes. No evidence of alternative splicing sites were found, excluding the possibility that T. solium expresses a mini-paramyosin like D. melanogaster.
