RESUMO
Aim: This study aimed to estimate the survival rates among Iranian gastric cancer patients and to evaluate if the survival has improved during the last three decades. Background: Gastric cancer is one of the most common cancers in Iran with high mortality. Methods: A systematic review and meta-analysis of all published studies addressing gastric cancer survival in Iran was performed. International databases of Scopus, Web of Science, PubMed, and Iranian databases were included in the study. The study included databases from their inception till February 2022. Due to the inherent heterogeneity, we used a random effect model to pool the survivals in three categories of one, three, and five-year survivals. Results: Thirty-three studies with total cases of 17,207 were included in the study. The overall (pooled) one, three, and five-year survivals were estimated as 58.9% (95% CI: 0.52, 0.66), 29.9% (95% CI: 0.25, 0.35), and 18.2% (95% CI: 0.15, 0.23), respectively. Results of subgroup analysis for the calendar years of study showed that the one, three, and five-year survival rates increased during the last three decades but the results were not statistically significant. There was the disparity in survival based on geographic distribution. Conclusion: The results of our study which has pooled many studies for a long period of time clearly indicate that the survival rates of gastric cancer patients have improved. As the improvement of survival may be due to many factors, more studies is needed to understand the dynamic behind this improvement.
RESUMO
BACKGROUND: Cancer is a major cause of morbidity and mortality worldwide. This study aimed to investigate the scale and nature of the socio-economic burdens that face families of children with pediatric cancer in Bangladesh on a day-to-day basis and the reasons for delays in diagnosis and treatment of the disease. METHODS: A cross-sectional exploratory study including 54 families in Bangladesh who had children with cancer. A structured questionnaire was used to collect quantitative data, supplemented by open-ended questions to gain in-depth information about specific issues. RESULTS: The majority of children were male (n=39, 72.2%) and aged 6-15 (n=38, 70.4%). Blood cancer (n=20, 37%) and acute lymphocytic leukemia (n=25, 46.3%) were the most common diagnoses. Many parents stopped working after their child's cancer diagnosis (n=28, 51.9%). Many families (n=21, 38.90%) spent more per month (e.g., USD 471-1,179) on their child's treatment than their income. No external financial support was available to cover this high expenditure, putting families under financial pressure. Social issues included fear, lack of cancer awareness, stigma in rural communities, low-quality facilities, inappropriate service provider behavior, poor facility hygiene, and high fees. CONCLUSION: This study revealed that childhood cancer has a substantial impact on parents' socioeconomic status, and many families face financial, social, and psychological challenges. This highlights the need for urgent collaborative action to address these problems.
