RESUMO
Hypomelanosis of Ito (HI) is a neurocutaneous syndrome characterized by hypopigmented cutaneous lesions and extracutaneous manifestations frequently affecting the nervous system and the musculoskeletal system. Dysmorphic features, dental, ophthalmic, gastrointestinal, cardiac, and renal abnormalities are described in a minority of patients. The authors describe a 4-month-old infant having HI with unusual pulmonary hypoplasia that has not been reported so far.
RESUMO
Amitraz is a formamidine insecticide and acaricide which acts on alpha 2-adrenergic receptors. There is little information available in the literature about the toxicity and treatment of poisoning by this compound. The authors report amitraz poisoning in a 13-y-old boy which was managed with supportive care with a good outcome.
Assuntos
Atropina/uso terapêutico , Dopamina/uso terapêutico , Inseticidas/intoxicação , Antagonistas Muscarínicos/uso terapêutico , Simpatomiméticos/uso terapêutico , Toluidinas/intoxicação , Adolescente , Quimioterapia Combinada , Hidratação/métodos , Seguimentos , Lavagem Gástrica/métodos , Humanos , Masculino , Receptores Adrenérgicos alfa 2/efeitos dos fármacos , Resultado do TratamentoAssuntos
Anticorpos Monoclonais/administração & dosagem , Endoftalmite/etiologia , Infecções Oculares Bacterianas/etiologia , Degeneração Macular/tratamento farmacológico , Fator A de Crescimento do Endotélio Vascular/antagonistas & inibidores , Procedimentos Cirúrgicos Ambulatórios , Anticorpos Monoclonais Humanizados , Bevacizumab , Endoftalmite/epidemiologia , Infecções Oculares Bacterianas/epidemiologia , Humanos , Injeções , Ranibizumab , Infecções Estafilocócicas/epidemiologia , Infecções Estafilocócicas/etiologia , Staphylococcus epidermidis/isolamento & purificação , Infecções Estreptocócicas/epidemiologia , Infecções Estreptocócicas/etiologia , Estreptococos Viridans/isolamento & purificação , Acuidade Visual , Corpo VítreoRESUMO
The regions of the developing craniofacial skeleton and gut of Xenopus laevis have been confronted in vivo with purified embryonic galactoside-binding lectin or its hapten inhibitor thiodigalactoside (TDG). Confrontation was carried out at stage 24-26 (cranial neural crest migrating). Further development of the head skeleton and gut has been monitored in living animals and in histological cross-sections of selected head regions. Lectin treatment correlates with the development of larger heads than controls. TDG treatment correlates with the development of narrower heads than controls. After both treatments, head cartilages are composed of fewer total chondrocytes. Both neural crest and non-neural crest cartilages are affected. The gut forms larger, irregular coils after lectin or TDG confrontation. The results suggest that galactoside-binding lectin/galactoside-bearing receptor adhesive interactions are important in development of the craniofacial/visceral skeleton and gut.
Assuntos
Embrião não Mamífero/efeitos dos fármacos , Hemaglutininas/metabolismo , Crista Neural/efeitos dos fármacos , Tiogalactosídeos/farmacologia , Xenopus laevis/embriologia , Animais , Cartilagem/embriologia , Sistema Digestório/embriologia , Embrião não Mamífero/metabolismo , Feminino , Galactosídeos/metabolismo , Galectinas , Cabeça/embriologia , Hemaglutininas/farmacologia , Larva/efeitos dos fármacos , Larva/metabolismo , Masculino , Morfogênese , Crista Neural/embriologia , Tiogalactosídeos/metabolismoRESUMO
A monoclonal antibody has been produced against Xenopus laevis galactoside-binding neural-crest-stage lectin. This antibody inhibits lectin-mediated hemagglutination. Using this antibody in conjunction with immunohistochemical techniques, lectin deposition has been studied in embryos and tadpoles at different stages of morphogenesis, from initial neural crest migration, up to the formation of a swimming tadpole. Lectin levels change during development in different regions of the embryo and tadpole, decreasing in migratory cells, and increasing in sites where cells become more adhesive to one another. The results suggest that galactoside-binding lectins may be an important class of cellular adhesion molecules during these stages of development.
