[The spatial-temporal organization of erythropoiesis in exposure of the body to hyperbaric oxygenation]. / Prostranstvenno-vremennáia organizatsiia éritropoéza pri vozdeistviiakh na organizm giperbaricheskoi oksigenatsii.

A systemic approach to appraisal of the mechanisms of changes of erythropoiesis biorhythms in stress is suggested. The authors studied the daily and seasonal rhythms of serum erythropoietin (EP) level, the production of erythrocytes (PE), the kinetics of bone marrow erythroid cells, and the activity of lipid peroxidation (LPO) and G-6-PDG in peripheral blood erythrocytes in albino rats. As a stress factor hyperbaric oxygenation initiated LPO acceleration and change of PE circadian rhythm with mesor decrease. Increased production of erythrocytes with reduction of their life span was simultaneously revealed. The differences in acrophases and amplitudes of erythropoiesis values in different seasons are caused by changes of erythroid cell kinetics due to mobilization of terminal erythropoiesis.