Bioavailability and Safety of Dihydroquercetin (Review).

Dihydroquercetin (DHQ) is a bioflavonoid with high antioxidant, capillary-protective, and anti-inflammatory activity. DHQ has previously been used for treating Middle East respiratory syndrome coronavirus (MERS-CoV) infection and is currently considered a potential regulator of oxidative stress as part of COVID-19 multipurpose therapy. DHQ has a high safety profile but low bioavailability that limits its use. Innovative techniques (liposomization, crystal engineering, etc.) can be used to increase its bioavailability.

[An objective relation approach in the modeling of dispensary registration of patients with tuberculosis].

The designing of an integrated information system of a tuberculosis dispensary (TD) has resulted in the construction and introduction of a model that is based on the concept of a uniform patient card, combines information on dispensary registration (DR) and striking off, as well as on the shifting of the TD-attached contingents between different DR groups. The system also contains a logic group that includes formalized descriptions of a tuberculous process. In addition, this model serves to integrate geoinformation technologies, as other information technologies (such as digital image acquisition, postprocessing, storage, and transmission) into its based information systems. This integrated information system permits a real-time quantitative analysis of the basic indices of the tuberculosis epidemic situation, which is necessary while planning tuberculosis-controlling measures, controlling their implementation, and correcting them at all levels.

[The characteristics of the functional status of the periodontal circulation following the preparation of pulpectomized teeth under artificial crowns]. / Osobennosti funktsional'nogo sostoianiia krovoobrashcheniia parodonta posle preparirovaniia depul'pirovannykh zubov pod iskusstvennye koronki.

Rheoparodontographic findings evidence more profound and manifest shifts in periodontal circulation of pulp-free teeth as against intact teeth after preparation for artificial crowns. Vascular elasticity and distensibility are reduced in pulp-free teeth, vascular tonic tension and periodontal tissue blood content are elevated (according to the inflammatory arterial hyperemia type), peripheral vascular resistance is reduced, and venous blood flow from the periodontal tissues deteriorated.

[Computer software and hardware requirements for the differential diagnosis of periodontal diseases using discriminant analysis]. / Programmno-apparatnoe obespechenie differentsial'noi diagnostiki zabolevanii parodonta s primeneniem diskriminantnogo analiza.

A method of differential diagnosis of parodontium diseases has been devised with the aid of a functional diagnostic system using multichannel rheo- and photoplethysmographs and the deciding rule of discriminant function computation in accordance with an algorithm elaborated. As many as 200 patients have undergone diagnostic examination with the aid of the above-indicated software and hardware system to demonstrate a high probability (92%) of diagnosis.

[The use of discriminant analysis for the differential diagnosis of periodontal diseases]. / Primenenie diskriminantnogo analiza dlia differentsial'noi diagnostiki zabolevanii parodonta.

Basing on rheo- and photoplethysmography combined with mathematical methods and computers the authors have developed a method for the differential diagnosis of periodontal diseases (gingivitis, periodontitis). Diagnostic studies carried out in 200 patients have shown a high probability (at least 92 percent) of the method for the differential diagnosis of periodontal diseases.