RESUMO
The authors describe a case of severe glaucoma in the only seeing eye of a patient with venous circulation disturbance resulting from a chronic anal fissure complicated with progressive anal stenosis, severe sphincter spasm, and pain syndrome. The article presents the results of multiple clinical ophthalmological tests and instrumental examinations performed before and after surgical intervention that evidence the importance of venous circulation disturbances for glaucoma development.
Assuntos
Procedimentos Cirúrgicos do Sistema Digestório/métodos , Fissura Anal/complicações , Glaucoma de Ângulo Aberto , Hipertensão Intra-Abdominal/complicações , Adulto , Doença Crônica , Constipação Intestinal/etiologia , Constipação Intestinal/fisiopatologia , Feminino , Fissura Anal/diagnóstico , Fissura Anal/fisiopatologia , Fissura Anal/cirurgia , Glaucoma de Ângulo Aberto/diagnóstico , Glaucoma de Ângulo Aberto/etiologia , Glaucoma de Ângulo Aberto/terapia , Humanos , Período Pós-Operatório , Resultado do TratamentoRESUMO
A case of Retinalamin (peptide-based drug) use in a patient with newly diagnosed glaucoma and therapeutically normalized intraocular pressure is reported. The results of visual field test (Humphrey Field Analyzer) and optic nerve examination (Heidelberg Retina Tomograph) as well as electrophysiological indices before and 1 and 3 month after the course of Retinalamin (10 parabulbar injections) are presented.
Assuntos
Glaucoma de Ângulo Aberto/complicações , Doenças do Nervo Óptico , Nervo Óptico , Peptídeos/administração & dosagem , Potenciais Evocados Visuais , Feminino , Glaucoma de Ângulo Aberto/diagnóstico , Glaucoma de Ângulo Aberto/tratamento farmacológico , Glaucoma de Ângulo Aberto/fisiopatologia , Humanos , Injeções Intraoculares , Pressão Intraocular/efeitos dos fármacos , Pessoa de Meia-Idade , Fármacos Neuroprotetores/administração & dosagem , Soluções Oftálmicas/uso terapêutico , Nervo Óptico/efeitos dos fármacos , Nervo Óptico/patologia , Nervo Óptico/fisiopatologia , Doenças do Nervo Óptico/diagnóstico , Doenças do Nervo Óptico/etiologia , Doenças do Nervo Óptico/fisiopatologia , Doenças do Nervo Óptico/terapia , Tomografia Óptica/métodos , Resultado do Tratamento , Testes de Campo Visual/métodosRESUMO
The effect of cavinton forte on visual functions and ocular hemodynamics was studied in patients with primary open-angle glaucoma (POAG). Fifty-three patients (97 eyes) aged 45 to 75 years (mean age 66.3 +/- 3.7 years) who had POAG were examined. A study group comprised 38 patients (67 eyes, including 24 with Stage Ia POAG, 27 with Stage IIa, 16 with Stage IIIa). All these patients took cavinton forte (10 mg) thrice daily for 2 months. A control group consisted of 15 patients (30 eyes) receiving no vasoactive agents. In these patients, intraocular pressure was normalized and it was in the range of 15 to 21 mm Hg after Goldmann. The use of the vasoactive drug cavinton forte improved and stabilized visual functions in POAG patients with normalized intraocular pressure, which is particularly important with advanced POAG. Increased blood flow velocity in the ocular arteries after a course of therapy with cavinton forte suggests a better retinal blood supply, which is a favorable marker for the prediction of the disease.
Assuntos
Anti-Hipertensivos/uso terapêutico , Glaucoma de Ângulo Aberto/tratamento farmacológico , Pressão Intraocular/efeitos dos fármacos , Vasos Retinianos/efeitos dos fármacos , Alcaloides de Vinca/farmacologia , Alcaloides de Vinca/uso terapêutico , Visão Ocular/efeitos dos fármacos , Idoso , Anti-Hipertensivos/administração & dosagem , Anti-Hipertensivos/farmacologia , Velocidade do Fluxo Sanguíneo , Glaucoma de Ângulo Aberto/classificação , Glaucoma de Ângulo Aberto/diagnóstico por imagem , Humanos , Pessoa de Meia-Idade , Fatores de Tempo , Resultado do Tratamento , Ultrassonografia Doppler , Alcaloides de Vinca/administração & dosagemRESUMO
Skin biopsy is the most significant method for diagnosis of microcirculatory disorders in diabetes mellitus of type 2 (DM2) and ischemic heart disease (IHD). This method provides earlier detection of microcirculatory changes which is essential for prophylaxis of life-threatening vascular complications and early treatment. 29 IHD and DM2 patients were examined. In the period of DM compensation and stable angina these patients underwent incision biopsy. Morphological preparations were studied histologically and immunohistochemically. The data obtained allowed estimation of the mean time of development of diabetic microangiopathy (MAP) in these patients. The results show that in combination of DM2 and IHD microcirculatory disorders in skin biopsies develop later than in DM2 without IHD; MAP progression correlates with DM duration; clinical compensation of patients with IHD and DM2 depresses progression of DMA. A method of choice in diagnosis of microcirculatory disorders in DM patients is skin biopsy.
