[Inoculation properties of live combined vaccine against measles and mumps]. / Privivochnye svoistva zhivoi assotsiirovannoi vaktsiny protiv kori i parotita.

The data obtained in the study of the immunization properties of experimental and production lots of combined parotitis-measles vaccine prepared at the Pasteur Research Institute for Epidemiology and Microbiology (Leningrad) in 1971-1979 are summarized. The preparation was shown to possess low reactogenicity and, at the same time, high immunogenic activity. The reactogenicity of the preparation depended mainly on the presence of the measles component in the divaccine and its immunogenicity, on the measles virus/parotitis virus ratio in one vaccination dose. The concentration of measles virus between 300 and 10000 infective units and parotitis virus between 5000 and 100000 infective units in one vaccination dose, as well as the age of the vaccinees, did not affect the immunization properties of the divaccine. The use of the combined vaccine in the foci of parotitis infection did not increase the reactogenicity of the preparation, but enhanced its immunogenic properties.

[Use of a 2-phase system of water-soluble polymers to concentrate measles and mumps virus]. / Primenenie dvukhfaznykh sistem vodorastvorimykh polimerov dlia kontsentrirovaniia virusov korov i parotita.

The possibility of using two-phase systems of water-soluble polymers, polyethylene glycol (PEG) (molecular weight 6000 daltons), dextran sulphate (DS) (molecular weight 500,000 daltons), PEG- dextran (D) (molecular weight 500,000 daltons) for concentration of measles and parotitis viruses was studied. Virus concentration was found to occur in the interphase and lower phase, and the coefficient of concentration for both viruses to be 300 in the PEG-DS system and 60-100 in PEG-D system.