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Vopr Med Khim ; 37(4): 54-6, 1991.
Artigo em Russo | MEDLINE | ID: mdl-1750212

RESUMO

Complex of vitamins E and C showed the most effective antinecrotic action in rats with simulated myocardial infarction in series of antioxidants studied: ascorbate, alpha-tocopherol, quercetine, derivatives of o-benzoquinone OBQ2 and OBQ3. Stabilization of lipid peroxidation in cardiomyocytes, increase in biomembranes stability and absence of distinct alterations in the antioxidative enzymatic system were found in rats with ischemia and myocardial infarction after treatment with the complex. Protective effect of the vitamins E and C complex was realised via antiradical mechanism.


Assuntos
Antioxidantes , Ácido Ascórbico/uso terapêutico , Doença das Coronárias/tratamento farmacológico , Infarto do Miocárdio/tratamento farmacológico , Vitamina E/uso terapêutico , Animais , Benzoquinonas/uso terapêutico , Catalase/sangue , Eritrócitos/enzimologia , Hemoglobinas/análise , Quercetina/uso terapêutico , Ratos , Ratos Endogâmicos
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