Benign Metastasizing Leiomyomatosis to the Skin and Lungs, Intravenous Leiomyomatosis, and Leiomyomatosis Peritonealis Disseminata: A Series of Five Cases.

Benign metastasizing leiomyomatosis (BML) is a rare disease that typically occurs in women with a history of uterine leiomyomatosis. Benign metastasizing leiomyomatosis occurs more frequently in the lungs but may also develop in other organs and tissues. Other unusual variants of extra-uterine leiomyomatosis include intravenous leiomyomatosis (IVL) and leiomyomatosis peritonealis disseminata (LPD). In this article, three cases of BML are presented. One case, in a premenopausal woman, presented cutaneous metastases. We also present a case of IVL and a case of LPD, which occurred in postmenopausal women. Given the rarity of BML, IVL, and LPD, the authors reviewed the literature and herein discuss the implications for treatment in all five cases. Evidence for treating BML, IVL, and LPD is still scarce, and data available from our series and other small series seem to point to the patient's hormonal status playing a fundamental part in the treatment plan. Furthermore, a collecting bag when performing excision of uterine leiomyomas may help avoid the potential spreading of leiomyomatosis. Hysterectomized patients with chronic cough, frequent respiratory infections, abdominal discomfort, right heart failure, or non-specific symptoms should be actively screened for BML, IVL, and LPD. Treatment should be individualized according to each patient's hormonal status and desires.

Sarcoma Metabolomics: Current Horizons and Future Perspectives.

The vast array of metabolic adaptations that cancer cells are capable of assuming, not only support their biosynthetic activity, but also fulfill their bioenergetic demands and keep their intracellular reduction-oxidation (redox) balance. Spotlight has recently been placed on the energy metabolism reprogramming strategies employed by cancer cells to proliferate. Knowledge regarding soft tissue and bone sarcomas metabolome is relatively sparse. Further characterization of sarcoma metabolic landscape may pave the way for diagnostic refinement and new therapeutic target identification, with benefit to sarcoma patients. This review covers the state-of-the-art knowledge on cancer metabolomics and explores in detail the most recent evidence on soft tissue and bone sarcoma metabolomics.

Influence of an Intervention on the Motor Coordination of Children from 5-6 Years / Influência de uma Intervenção sobre a Coordenação Motora de Crianças de 5-6 Anos

In Infant Education the presence of the Physical Education teacher is not legitimized by law yet, however the literature evidences how the motor experiences are important during childhood. The varied interactions and deprivation of experiences have the potential to influence the child's development. Thus, the objective of the study was to determine the effects of a pedagogical intervention of Physical Education, on the motor coordination of children from 5-6 years, in a specific elementary school. The participants were two groups: the experimental group (n = 10) and the control group (n = 25). The experimental group performed ten sessions of ludic activities, motor for 60 minutes, once a week, in space destined for body movement. At the beginning and end of the intervention all participants were evaluated by the Körperkoordination Test für Kinder (KTK). The results showed that the experimental group presented significant statistical improvements in the motor coordination when compared to the control group. Thus, the inclusion of the Physical Education teacher in the first stage of Basic Education becomes important, since it can contribute with the offer of diversified motor experiences and the development of young children. (AU)

Na Educação Infantil a presença do professor de Educação Física ainda não é legitimada por lei; porém, a literatura evidência como as vivências motoras são importantes na infância. As variadas interações e as privações de experiências apresentam potencial para influenciar o desenvolvimento da criança. Neste sentido, o objetivo do estudo foi determinar os efeitos de uma intervenção pedagógica da Educação Física sobre a coordenação motora de crianças de 5-6 anos de uma escola específica de Educação Infantil. Os participantes constituíram dois grupos: grupo experimental (n=10) e grupo controle (n=25). O grupo experimental realizou dez sessões de atividades motoras lúdicas, durante 60 minutos, uma vez por semana, em espaço destinado a movimentação corporal. No início e término da intervenção todos os participantes foram avaliados pelo Körperkoordination Test für Kinder (KTK). Os resultados demonstraram que o grupo experimental apresentou avanços significativos estatisticamente na coordenação motora, quando comparado ao grupo controle. Assim, a inclusão do professor de Educação Física, na primeira etapa da Educação Básica se faz importante, pois pode contribuir com o oferecimento de experiências motoras diversificadas e com o desenvolvimento das crianças pequenas. (AU)

O circo na educação infantil: vivências e representações artísticas / The circus in early childhood education: experiences and artistic representations in drawing / El circo en la educación infantil: experiencias y representaciones artísticas en el dibujo

O circo sempre fez parte do mundo infantil, despertando magia, alegria e sonhos. Este estudo analisou representações e apropriações das crianças sobre o circo, a partir de seus próprios desenhos, elaborados numa proposta de atividades circenses. Consistiu num estudo de caso, com 21 crianças de uma escola de Educação Infantil, com idade entre 4 a 5 anos. Observou-se que antes da proposta a estrutura externa do circo, a lona, foi o elemento mais representado pelas crianças, sugerindo este fato, que embora algumas crianças nunca tivessem presenciado um espetáculo de circo, conheciam sua estrutura física que em algum momento lhes foi apresentada. Após 12 sessões da proposta pedagógica, a lona do circo deixou de ser o elemento mais representado, surgindo protagonistas, como o malabarista e o mágico. Ficou evidenciado que vivências corporais e o diálogo permitiram ressignificar o circo na Educação Infantil.

The circus has always maintained a close relation with the children's universe, stimulating magic, joy and dreams. This study analysed the children´s understanding of the circus representations and appropriations, based on their own drawings about the circus activities. It consisted of a case study of 21 children aged between 4 and 5 years old, from a kindergarten institution. It was observed that before the proposal the external structure of the circus, the canvas, was the element most represented by the children, suggesting that although some children had never seen a circus spectacle before, they were already introduced to some of its physical structure. After 12 sessions of the pedagogical proposal, the canvas of the circus was no longer the most represented element, but also the protagonists, juggler and magicians. It was evidenced that the physical activities and dialogues have allowed the circus to be re-signified on Early Childhood Education.

El circo siempre mantuvo estrecha la relación con el universo infantil, despertando magia, alegría y sueños. Este estudio analizó representaciones y apropiaciones de los niños sobre el circo, a partir de sus propios dibujos, elaborados en una propuesta de actividades circenses. Consistió en un estudio de caso, con 21 niños de una institución de educación infantil, con edad entre 4 y 5 años. Se observó que antes de la propuesta la estructura externa del circo, la lona, fue el elemento más representado por los niños, sugiriendo este hecho, que aunque algunos niños nunca habían presenciado un espectaculo de circo, conocían su estructura física que en algún momento les fue presentada. Después de 12 sesiones de la propuesta pedagógica, la lona del circo dejó de ser el elemento más representado, surgiendo protagonistas, como el malabarista y el magico. Se evidenció que vivencias corporales y el diálogo permitieron resignificar el circo en la educación infantil