RESUMO
Congenital syphilis still represents a significant public health problem worldwide, and particularly in developing countries. Despite years of research on different clinical and immunological features, many physiopathological aspects still lacks of knowledge, one of them the role of immune response against Treponema pallidum by infected mothers on the birth outcomes, e.g. birthweight. In this study we analyzed if the mother VDRL titers were significantly associated with the birthweight of newborns with congenital syphilis. We observed a highly significant association between both variables, finding at the linear regression that with higher mother VDRL titers, the newborn birthweight was lower (p=0.0345). We identified that higher VDRL titers are associated with lower birth weights, although the physiopathological reasons to explain this still remains unclear.
Assuntos
Anticorpos Antibacterianos/sangue , Recém-Nascido de Baixo Peso , Resultado da Gravidez , Sorodiagnóstico da Sífilis/métodos , Sífilis Congênita/fisiopatologia , Sífilis/diagnóstico , Treponema pallidum/imunologia , Feminino , Humanos , Recém-Nascido , Masculino , Gravidez , Complicações Infecciosas na Gravidez/imunologia , Complicações Infecciosas na Gravidez/microbiologia , Sífilis/imunologia , Sífilis/microbiologia , Sífilis Congênita/diagnóstico , Sífilis Congênita/imunologia , Sífilis Congênita/microbiologiaRESUMO
Congenital syphilis still poses a significant public health problem in many countries of the world. We studied epidemiology of syphilis and other sexually transmitted infections among pregnant women and their newborns during a 5-year period at a general hospital in Valera, western Venezuela finding a high incidence of disease among those newborns from infected mothers.
