1.
Chemistry
; 19(30): 9973-8, 2013 Jul 22.
Artigo
em Inglês
| MEDLINE
| ID: mdl-23765568
RESUMO
A challenging asymmetric reaction (aza-Michael addition of imides to enones) has been optimized through an integrated approach involving the synthesis of a family of organocatalysts, multiple catalysis (usage of additives), and finally with rational exploration of the chemical space by the application of the experiment design.