1.
Eur J Med Chem
; 45(5): 1828-32, 2010 May.
Artigo
em Inglês
| MEDLINE
| ID: mdl-20122766
RESUMO
Synthesis of 3,3'-(1,4-phenylene)-bis[2-alkoxycarbonyl-alkyl)-2-thio-benzoxaphos-phinines] (3a-j) were accomplished via two step process. It involves the prior preparation of monochloride intermediate (2) and its subsequent reaction with the amino acid esters in dry tetrahydrofuran-toluene in the presence of triethylamine at reflux temperature. These compounds were characterized by IR, 1H, 13C, 31P NMR and were found to exhibit potent in vitro antioxidant activity.