Agreement between stress intraocular pressure and long-term intraocular pressure measurements in primary open angle glaucoma.

PURPOSE: The aim of this paper is to study the correlation between the intraocular pressure peaks and fluctuation detected during the water drinking test and the same parameters observed during long-term follow up. METHODS: This prospective cohort study enrolled 22 eyes of 22 newly diagnosed primary open angle glaucoma patients. After an initial complete ophthalmological examination, patients were started on antiglaucoma medication and returned 4 weeks later to perform the water drinking test. Thereafter,patients were evaluated at least eight times within a period of 6-12 months. The intraocular pressure peaks and fluctuation detected during the water drinking stress test were compared with those observed during regular office visits. Spearman's correlation coefficient and Bland-Altman Plots were used for statistical analysis. RESULTS: The mean age of participants was 54.3 +/- 8.2 years (+/-SD), 59% were women, and average mean deviation -10.2 +/- 4.5 dB. The mean follow-up period was 8.2 +/- 2.0 months. The average intraocular pressure peaks and fluctuation during the water drinking test were 20.0 +/- 2.9 mmHg and 40 +/- 10%, respectively, and 18.1 +/- 2.8 mmHg and 30 +/- 10% during follow up. Spearman's correlation coefficients were significant and strong between the intraocular pressure peaks and fluctuation detected during the water drinking test and during the follow-up period (P < 0.001, rho = 0.76 and 0.82,respectively). There was good agreement between the variables. CONCLUSION: The intraocular pressure peaks and fluctuation detected during the water drinking test showed significant correlation and agreement with the pressures observed during follow-up visits. Stress tests could be used to estimate long-term intraocular pressure variation.

Prevalence of open angle glaucoma in accompanying first degree relatives of patients with glaucoma.

OBJECTIVE: The aim of this study was to determine the prevalence of open angle glaucoma in first-degree relatives accompanying POAG patients during routine examination in a reference hospital. METHOD: First-degree relatives of primary open angle glaucoma patients who accompanied their relatives to the glaucoma service of a reference hospital were screened for glaucoma. RESULTS: One-hundred and one first-degree relatives were examined, of which 56.4% had never had their intraocular pressure measured. 10.9% had previously been diagnosed with glaucoma, and 5.9% were newly diagnosed during this study. CONCLUSIONS: The eye examination of first-degree relatives identified a significant percentage of individuals with glaucoma. Despite being first-degree relatives of glaucoma patients, 56.4% of the companions had never had their eye pressure measured, demonstrating a lack of awareness about this disease.

Prevalence of open angle glaucoma in accompanying first degree relatives of patients with glaucoma

OBJECTIVE: The aim of this study was to determine the prevalence of open angle glaucoma in first-degree relatives accompanying POAG patients during routine examination in a reference hospital. METHOD: First-degree relatives of primary open angle glaucoma patients who accompanied their relatives to the glaucoma service of a reference hospital were screened for glaucoma. RESULTS: One-hundred and one first-degree relatives were examined, of which 56.4 percent had never had their intraocular pressure measured. 10.9 percent had previously been diagnosed with glaucoma, and 5.9 percent were newly diagnosed during this study. CONCLUSIONS: The eye examination of first-degree relatives identified a significant percentage of individuals with glaucoma. Despite being first-degree relatives of glaucoma patients, 56.4 percent of the companions had never had their eye pressure measured, demonstrating a lack of awareness about this disease.

[Mantle-cell lymphoma of the ocular adnexa: a case report]. / Linfoma de células da zona do manto em anexos oculares: relato de caso.

Ocular adnexal lymphoid tumors are slow-growing neoplasms that affect predominantly the elderly. The purpose of this study is to report a non-Hodgkin lymphoma from mantle zone cells, a rare ocular annexal B-cell lymphoma subtype. CASE REPORT: A 62-year-old male patient with superior eyelid, maxillary and oral tumours, had an initial diagnosis of Mikulics disease, developed lesion enlargement, despite immunosuppressant therapy. Left superior eyelid and bone marrow biopsy revealed non-Hodgkin lymphoma the mantle zone. In spite of dissemination (stage IV), chemotherapy and bone marrow transplant led to disease remission. CONCLUSIVE COMMENTARIES: Despite the availability of advanced complementary diagnostic methods, like immunophenotyping and molecular genetic analysis, lymphoma represents, for physicians and pathologists, a challenge regarding diagnosis and prognosis.

Linfoma de células da zona do manto em anexos oculares: relato de caso / Mantle-cell lymphoma of the ocular adnexa: a case report

Os tumores linfóides dos anexos oculares são neoplasias de crescimento lento que acometem principalmente idosos. O objetivo deste trabalho é relatar um caso de linfoma não-Hodgkin de células da zona do manto, um subtipo raro de linfoma de células B nos anexos oculares. RELATO DO CASO: Paciente masculino de 62 anos com tumoração em pálpebras superiores, região maxilar e cavidade oral, tendo o diagnóstico inicial de doença de Mikulics, evoluiu com acentuado aumento das lesões, apesar da terapêutica imunossupressora. Biopsias da pálpebra superior esquerda e medula óssea revelaram linfoma não-Hodgkin de células B da zona do manto. Apesar da disseminação (estadiamento grau IV), quimioterapia e transplante de medula óssea conduziram à remissão da doença. COMENTARIOS CONCLUSIVOS: Apesar da disponibilidade de avançados métodos diagnósticos complementares como a imunofenotipagem e a análise genética molecular, o linfoma representa, para clínicos e patologistas, um desafio quanto ao diagnóstico e ao prognóstico.

Análise dos casos de retinoblastoma atendidos no Hospital Regional de São José / Analysis of the taken care cases of retinoblastoma at the Hospital Regional de São José

Objetivo: Avaliar os casos de retinoblastoma atendidos no Departamento de Plástica Ocular do Serviço de Oftalmologia do Hospital Regional de São José - Homero de Miranda Gomes (HRSJ-HMG), no período de 1994 a 2003, determinando faixa etária mais acometida, tipo histológico mais freqüente e precocidade no tratamento. Método: Estudo de casos, retrospectivo e histórico de 18 pacientes com retinoblastoma, avaliando as variáveis: idade da criança na primeira consulta; olho(s) acometido(s); sexo; principais sinais e sintomas na primeira consulta; exames complementares utilizados no diagnóstico; resultado do anátomo-patológico; tratamento realizado; tempo de acompanhamentoapós o tratamento. Resultado: A idade média das crianças ao diagnóstico foi de 2,5 anos (±1,53). Não houve diferença entre os sexos dos afetados. Cinco casos foram bilaterais e treze unilaterais, sendo o olho esquerdo discretamente mais afetado que o direito. O sinal clínico mais freqüentemente encontrado foi a leucocoria (66,6%). A enucleação foi o tratamento realizado em 17 pacientes. Necrose e calcificação foram os achados predominantes no anátomo-patológico (77,7% e 66,6%, respectivamente). O tempo médio de acompanhamento foi de 10,7 meses (± 11,9 meses). Conclusão: Neste estudo, a idade média ao diagnóstico foi de 2,5 anos. Não houve diferença estatística significativa entre os sexos dos afetados. A maioria dos tumores foi unilateral. O tratamento predominante foi a enucleação. Todos estes dados estão de acordo com a literatura...