Nivel de comunicación familiar y autoeficacia en pacientes con Diabetes Mellitus tipo 2 en atención primaria de salud / Level of family communication and self-efficacy in patients with type 2 Diabetes Mellitus in primary health care primary health care

Objetivo principal: establecer la relación entre el nivel de comunicación familiar y autoeficacia en pacientes con Diabetes Mellitus Tipo 2 que asisten a un centro de salud primaria. Metodología: Estudio analítico de corte transversal, con una muestra de 238 pacientes con DM2 a los que se les aplicó la Escala de Comunicación Familiar de FACES IV y la Escala de Autoeficacia en Diabetes. Resultados principales: El 75,6% identificó un nivel de comunicación familiar “muy alto” relacionado significativamente con el “apoyo de parientes” (p=0,001). La autoeficacia percibida presentó un puntaje general de 8,2 con correlación altamente significativa entre nivel de comunicación y los ítems de autoeficacia (p < 0,05). Los mayores puntajes de autoeficacia se concentraron en niveles “muy alto” de comunicación familiar. Conclusión principal: Una alta comunicación familiar puede impactar positivamente en la autopercepción y el empoderamiento del paciente en el manejo de su DM2.(AU)

Objective: to establish the relationship between the level of family communication and self-efficacy in patients with Type 2 Diabetes Mellitus attending a primary health center. Methodology: Cross-sectional analytical study. A sample of 238 patients with T2DM was obtained and administered the FACES IV Family Communication Scale and the Diabetes Self-Efficacy Scale. Results: 75.6% identified a "very high" level of family communication significantly related to "support from relatives" (p=0.001). Perceived self-efficacy had an overall score of 8.2 with a highly significant correlation between level of communication and self-efficacy items (p-value < 0.05). The highest self-efficacy scores were concentrated in "very high" levels of family communication. Conclusion: High family communication can positively impact the patient’s self-perception and empowerment in the management of their T2DM.(AU)

Plasma from Patients with Rheumatoid Arthritis Reduces Nitric Oxide Synthesis and Induces Reactive Oxygen Species in A Cell-Based Biosensor.

Rheumatoid arthritis (RA) has been associated with a higher risk of developing cardiovascular (CV) diseases. It has been proposed that systemic inflammation plays a key role in premature atherosclerosis development, and is therefore crucial to determine whether systemic components from RA patients promotes endothelial cell-oxidative stress by affecting reactive oxygen species (ROS) and nitric-oxide (NO) production. The aim of this study was to evaluate whether plasma from RA patients impair NO synthesis and ROS production by using the cell-line ECV-304 as a biosensor. NO synthesis and ROS production were measured in cells incubated with plasma from 73 RA patients and 52 healthy volunteers by fluorimetry. In addition, traditional CV risk factors, inflammatory molecules and disease activity parameters were measured. Cells incubated with plasma from RA patients exhibited reduced NO synthesis and increased ROS production compared to healthy volunteers. Furthermore, the imbalance between NO synthesis and ROS generation in RA patients was not associated with traditional CV risk factors. Our data suggest that ECV-304 cells can be used as a biosensor of systemic inflammation-induced endothelial cell-oxidative stress. We propose that both NO and ROS production are potential biomarkers aimed at improving the current assessment of CV risk in RA.