[Temporal organization of external respiratory function in elderly patients with chronic obstructive lung disease]. / Temporal organization of external respiratory function in elderly patients with chronic obstructive lung disease.

The clinical course and the circadian, circaseptan, and circasemiseptan chronostructure of external respiratory function (ERF) were studied in 26 elderly patients with chronic obstructive lung diseases before and after routine therapy (RT). ERF was studied on a meta-test spirograph (Russia) and a Ferraris medical peak flowmeter (UK). The values of ERF and bronchial patency were measured every 4 hours within 7 days before and after 10-day RT. The latter included euphylline, expectorants, and antibacterial drugs, if indicated. The patients also use "on-demand" dosage aerosol inhalators not more than 3-5 times a day. The chronobiological data were analyzed by the averaged group cosinor test described by F. Halberg. The results of the study made it possible to detect the impaired temporary organization of ERF and bronchial patency, the phenomena of external and internal desynchronism both prior to and following RT. It clinical effect occurred on day 5.5 after RT. Before RT, circadian variations were found in respiratory volume (RV), respiratory minute volume (RMV), vital capacity (VC), forced expiratory value per sec (FEV1), the Tiffeneau test, and peakflowmetry. After RT, they remained other than variations in RV. The average daily values of VC, FEV1, Tiffeneau test, PO2, and KIO2 statistically significantly increased. The increases of MESORs and other indices tended to be significant. Circasemiseptan variations were found in RV, VC, and FEV1 before RT. After treatment, these were detected in respiration rate (RR), RMV, VC, and KIO2. The MESORs of RMV, VC, FEV1, and KIO2 statistically significantly increased. Prior to and following RT, there were virtually no 7-day (circaseptan) variations, other than those in RR before therapy. The MESORs of VC, FEV1, MVL, and RD statistically significantly increased. The MESORs of other parameters of ERF tended to be significant. Thus, RT led to the improved circadian and circasemiseptan organization of ERF and, to a lesser degree, to that of circaseptan chronostructure of the parameters of ERF.

[Effects of nebuliser treatment with berotec on external respiratory function, bronchial permeability, hemodynamics, acid-alkaline balance, oxygen saturation, and their circadian structure in elderly patients with chronic obstructive pulmonary disease]. / Vliianie nebulaizernoi terapii berotekom na funktsiiu vneshnego dykhaniia, bronkhial'nuiu prokhodimost', gemodinamiku, kislotno-shchelochnoe sostoianie, saturatsiiu kisloroda i ikh vremennuiu organizatsiiu u pozhilykh bol'nykh khronicheskoi obstruktivnoi bolezn'iu legkikh.

AIM: To study the effects of nebuliser therapy with berotek on clinical symptoms, external respiration function (ERF), bronchial permeability, hemodynamics and their temporal organisation in elderly patients with chronic obstructive pulmonary disease (COPD). MATERIAL AND METHODS: The study enrolled 20 COPD patients (mean age 64.9 +/- 1.9 years) with obstructive respiratory insufficiency of the second-third degree given nebuliser therapy with berotek as adjuvant to conventional treatment (the study group) and 12 COPD patients (mean age 69.7 +/- 2.5 years) given only conventional treatment (the control group). The following parameters were examined: ERF, BP, HD, AAB, OS (SaO2) in venous blood before and after treatment. Chronobiological studies of BP and HD were performed for 7 days at the beginning and end of the study. RESULTS: Berotek efficacy manifested on the treatment day 3 as improvement in the symptoms, IRF, BP, a rise in SaO2 and PaCO2 and a fall in PaCO2 in venous blood. Circadian chronostructure of peakflowmetry, systolic and diastolic blood pressure, mean arterial pressure persisted. Circaseptal and circasemiseptal rhythms of BP and HD disappeared. CONCLUSION: Nebuliser therapy with berotek has a positive effect on clinical symptoms, ERF, BP, gas exchange in the lungs, SaO2, HD and their circadian chronostructure.