RESUMO
The increase of dermathophytosis in patients with poor therapeutic response leads us to study the antifungal susceptibility of 36 clinical isolates to itraconazole, ketoconazole and fluconazole by the E-test method. According to established parameters by the Clinical Laboratory Standards Institute, the resistance to one or more antifungal drugs was demonstrated in seven isolates (19.4%) as follows: three Trichophyton rubrum, three T. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant to the three azolic drugs; the other six only to fluconazole. It is important to establish the antifungal susceptibility as part of the study procedures in patients with dermatophytosis and a poor antifungal response.
Assuntos
Antifúngicos/farmacologia , Farmacorresistência Fúngica Múltipla , Fluconazol/farmacologia , Itraconazol/farmacologia , Cetoconazol/farmacologia , Tinha/microbiologia , Trichophyton/efeitos dos fármacos , Adulto , Infecção Hospitalar/microbiologia , Farmacorresistência Fúngica , Epidermophyton/efeitos dos fármacos , Epidermophyton/isolamento & purificação , Feminino , Humanos , Masculino , México , Microsporum/efeitos dos fármacos , Microsporum/isolamento & purificação , Onicomicose/microbiologia , Tinha do Couro Cabeludo/microbiologia , Tinha dos Pés/microbiologia , Trichophyton/isolamento & purificaçãoRESUMO
Ante el aumento de pacientes con dermatofitosis y mala respuestaterapéutica, se estudió la sensibilidad antifúngica a itraconazol, ketoconazoly fluconazol por el método E-test, en 36 aislamientos clínicos de dermatofitos.Considerando los parámetros del Clinical Laboratory Standards Institute, seencontró resistencia a uno o mas antifúngicos en siete aislamientos (19,4%):tres de Trichophyton rubrum, tres de Trichophyton mentagrophytes y uno deTrichophyton tonsurans. Un aislamiento de T. rubrum mostró resistencia a lostres azoles y los seis restantes únicamente a fluconazol.Es importante establecer la sensibilidad antifúngica como parte del protocolode estudio de pacientes con dermatofitosis con mala respuesta terapéutica(AU)
The increase of dermathophytosis in patients with poor therapeutic responseleads us to study the antifungal susceptibility of 36 clinical isolates toitraconazole, ketoconazole and fluconazole by the E-test method.According to established parameters by the Clinical Laboratory StandardsInstitute, the resistance to one or more antifungal drugs was demonstrated inseven isolates (19.4%) as follows: three Trichophyton rubrum, threeT. mentagrophytes and one T. tonsurans. A T. rubrum isolate was resistant tothe three azolic drugs; the other six only to fluconazole.Its important to establish the antifungal susceptibility as part of the studyprocedures in patients with dermatophytosis and a poor antifungal response(AU)
