RESUMO
BACKGROUND: The use of eculizumab during pregnancy has generally been discouraged. Published data on related studies provides conflicting information and establishing a benefit-risk relationship proves to be a complicated task. Miscarriage rates, concomitant medications, and the stages of pregnancy when eculizumab treatment was initiated varied among the patients included in the case series. The aim of this report is to discuss eculizumab use during pregnancy. CASE PRESENTATION: A case of a woman diagnosed with Paroxysmal Nocturnal Hemoglobinuria (PNH) and treated with eculizumab, who expressed desire for pregnancy is presented. Six months after her eculizumab treatment, the patient experienced spontaneous abortion in her first trimester. The direct relation between eculizumab and the miscarriage is not clear. Other factors may have influenced this case, thus demonstrating the difficulty of managing pregnancy in women with PNH. CONCLUSION: Controversy on eculizumab risk during pregnancy encourages further review on its use, highlighting the importance to assess each case individually.
RESUMO
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Assuntos
Humanos , Masculino , Idoso , Fosfatidilinositol 3-Quinases/uso terapêutico , Rituximab/uso terapêutico , Ciclofosfamida/uso terapêutico , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Citomegalovirus , Infecções Respiratórias/induzido quimicamente , Digoxina/uso terapêutico , Combinação Trimetoprima e Sulfametoxazol/uso terapêutico , Ganciclovir/uso terapêutico , Pneumopatias/tratamento farmacológico , Clorambucila/uso terapêutico , Levofloxacino/uso terapêutico , Infecções por Citomegalovirus/tratamento farmacológico , Infecções Respiratórias/complicações , Infecções Respiratórias/terapia , Fosfatidilinositol 3-Quinases/efeitos adversosAssuntos
Antineoplásicos/efeitos adversos , Pneumopatias/microbiologia , Purinas/efeitos adversos , Quinazolinonas/efeitos adversos , Idoso , Antineoplásicos/uso terapêutico , Feminino , Humanos , Leucemia Linfocítica Crônica de Células B/tratamento farmacológico , Pneumopatias/etiologia , Pneumopatias Fúngicas/etiologia , Pneumopatias Fúngicas/microbiologia , Purinas/uso terapêutico , Quinazolinonas/uso terapêuticoRESUMO
No disponible