1.
Mol Biosyst
; 13(11): 2222-2225, 2017 Oct 24.
Artigo
em Inglês
| MEDLINE
| ID: mdl-28967020
RESUMO
Mannose-modified lectin-binding peptides were obtained from an α-helical-designed peptide phage library. Concanavalin A (ConA) was used as a representative target protein for the lectin family. The identified glycopeptides could selectively bind to ConA with micromolar affinity. With these results, the methodologies described in this study will enhance the selection of saccharide-modified ligands through the synergistic effects of sugar and peptide units, with better specificity and affinity towards lectin proteins.