RESUMO
Linear IgA disease is one of the rarer subepidermal blistering diseases. Linear IgA disease is a chronic, acquired, autoimmune blistering disease that is characterized by subepidermal blistering and linear deposition of IgA basement membrane antibodies. The disease affects both children and adults and, although there are some differences in their clinical presentations, there is considerable overlap with shared immunopathology and immunogenetics.
Assuntos
Autoantígenos/imunologia , Doenças Autoimunes/diagnóstico , Imunoglobulina A/imunologia , Colágenos não Fibrilares/imunologia , Dermatopatias Vesiculobolhosas/diagnóstico , Pele/imunologia , Adulto , Animais , Autoanticorpos/imunologia , Doenças Autoimunes/etiologia , Doenças Autoimunes/imunologia , Doenças Autoimunes/fisiopatologia , Criança , Diagnóstico Diferencial , Gastroenteropatias/complicações , Humanos , Neoplasias/complicações , Pele/patologia , Dermatopatias Vesiculobolhosas/etiologia , Dermatopatias Vesiculobolhosas/imunologia , Dermatopatias Vesiculobolhosas/fisiopatologia , Ferimentos e Lesões/complicações , Colágeno Tipo XVIIRESUMO
Linear IgA disease is one of the rarer subepidermal blistering diseases. Linear IgA disease is a chronic, acquired, autoimmune blistering disease that is characterized by subepidermal blistering and linear deposition of IgA basement membrane antibodies. The disease affects both children and adults and, although there are some differences in their clinical presentations, there is considerable overlap with shared immunopathology and immunogenetics.
Assuntos
Membrana Basal/imunologia , Imunoglobulina A/imunologia , Dermatopatias Vesiculobolhosas , Pele/imunologia , Idade de Início , Membrana Basal/patologia , Humanos , Pele/patologia , Dermatopatias Vesiculobolhosas/etiologia , Dermatopatias Vesiculobolhosas/imunologia , Dermatopatias Vesiculobolhosas/patologiaRESUMO
Microsporum canis is the causative organism in less than 10% of all tinea capitis infections in the UK. Transmission is generally via contact with an infected family pet and there are only rare reports of case clustering. This article describes an outbreak of M. canis in a primary school classroom demonstrating human-to-human spread from an index case who was presumed to have acquired the infection prior to arriving in the UK. There was no suggestion of clinical improvement following 4 weeks of oral terbinafine 125 mg daily and treatment was changed to griseofulvin. The Health Protection team screened class members and confirmed cases (either clinically or mycologically) were also treated with griseofulvin 10-20 mg/kg/day for 10 weeks. Classmates and siblings of classmates were recommended to use selenium sulphide or ketoconazole-containing shampoo twice weekly.
Assuntos
Antifúngicos/uso terapêutico , Transmissão de Doença Infecciosa , Microsporum/isolamento & purificação , Instituições Acadêmicas , Tinha do Couro Cabeludo/tratamento farmacológico , Tinha do Couro Cabeludo/transmissão , Criança , Relação Dose-Resposta a Droga , Humanos , Masculino , Tinha do Couro Cabeludo/microbiologia , Resultado do TratamentoRESUMO
A 16-year-old boy presented with painless swellings localized to the radial and ulnar aspects of his second through to the fifth fingers on the left hand, with more subtle changes affecting two fingers on the opposite hand. This had developed in the absence of mechanical trauma. Investigations for an arthropathy were negative, while a biopsy showed marked epidermal hyperplasia and an expanded dermis. These features are typical of pachydermodactyly, a benign dermatosis of uncertain aetiology. The interesting feature of this case is the presence of knuckle pads in the father of the patient, which raises the possibility that these two similar entities are related.
