RESUMO
The multipurpose dry chemical fire extinguishers are unusually efficient in extinguishing many classes of fire: A) ordinary combustible; B) flammable liquids and C) electrical equipment. This exemplary performance of multipurpose extinguishers is associated with minimal toxic effects to humans. Following contact of soft tissue with the multipurpose dry chemical, the tissue exhibits a remarkable ability to resist infection and a normal capacity to heal following injury. This negligible toxicity of the multipurpose dry chemicals makes them safe for extinguishing the flaming clothes of human burn victims.
Assuntos
Bicarbonatos/toxicidade , Queimaduras/fisiopatologia , Sistemas de Combate a Incêndio , Incêndios , Potássio/toxicidade , Compostos de Amônio Quaternário/toxicidade , Cicatrização/efeitos dos fármacos , Animais , Fagocitose/efeitos dos fármacos , Fosfatos/toxicidade , Coelhos , Infecção dos Ferimentos/fisiopatologiaRESUMO
The results of this study indicate that short term treatment of wounds with topical enzymes appears to be safe and is accompanied by no clinically significant side-effects. Topical wound treatment with this enzyme did not interfere either with healing of experimental wounds or the activity of the antibiotics. Wounds subjected to this enzyme treatment exhibited a normal capacity to resist infection, even though this enzyme interferred with leukocyte phagocytosis in vitro. The potential benefits of this treatment in experimental wounds as an adjunct to antibiotics considerably outweigh its damaging effects. Its clinical use in patients must await the results of carefully controlled clinical trials in which the efficacy of this treatment is evaluated.
Assuntos
Peptídeo Hidrolases/efeitos adversos , Administração Tópica , Animais , Antibacterianos/administração & dosagem , Antibacterianos/uso terapêutico , Cobaias , Leucócitos/efeitos dos fármacos , Masculino , Peptídeo Hidrolases/administração & dosagem , Peptídeo Hidrolases/uso terapêutico , Fagocitose/efeitos dos fármacos , Infecção da Ferida Cirúrgica/prevenção & controle , Fatores de Tempo , Cicatrização/efeitos dos fármacosRESUMO
The harmful influences of devitalized tissue on wound defenses are documented and the importance of wound debridement in the care of the traumatic wound is stressed. All devitalized soft tissues damaged the host's defenses and encouraged the development of infection. The capacity of divitalized muscle, fat, and skin to enhance infection was comparable. The infection-potentiating effect of skin was enhanced by exposing it to a dry thermal injury. The mechanisms by which devitalized soft tissue enhanced infection are several. The devitalized soft tissue acts as a culture medium promoting bacterial growth. In addition, the devitalized tissue inhibits leukocyte phagocytosis of bacteria and subsequent kill. Finally, the anaerobic environment within the devitalized tissue may also limit leukocyte function.
